Abstract
Objective and Background: Hydrazonoyl halides were used as precursors for the synthesis of a new series of bis-spiropyrazoles via reaction with 3,5-diarylidene-piperidone derivatives under ultrasound irradiation. The products were secluded in good yield after short reaction periods.
Conclusion: The anticancer activity of bis-spiropyrazoles against HepG2 (hepatic cancer), A549 (lung cancer) and CaCo2 (colon cancer) cell lines was screened. Three tested compounds 4b, 4c and 4f showed promising activity.
Keywords: Antitumor activity, Bis-spiropyrazoles, 3, 5-diarylidene-piperidones, hydrazonoyl halides, spiropiperidinecarbinols, ultrasound irradiation.
Mini-Reviews in Medicinal Chemistry
Title:Synthesis of New Bis-Spiropyrazoles as Antitumor Agents under Ultrasound Irradiation
Volume: 18 Issue: 7
Author(s): Naglaa A. Abdel Hafez, Huwaida M.E. Hassaneen, Thoraya A. Farghaly*, Sayed M. Riyadh and Heba S.A. Elzahabi
Affiliation:
- Department of Chemistry, Faculty of Science, Cairo University, Giza 12613,Egypt
Keywords: Antitumor activity, Bis-spiropyrazoles, 3, 5-diarylidene-piperidones, hydrazonoyl halides, spiropiperidinecarbinols, ultrasound irradiation.
Abstract: Objective and Background: Hydrazonoyl halides were used as precursors for the synthesis of a new series of bis-spiropyrazoles via reaction with 3,5-diarylidene-piperidone derivatives under ultrasound irradiation. The products were secluded in good yield after short reaction periods.
Conclusion: The anticancer activity of bis-spiropyrazoles against HepG2 (hepatic cancer), A549 (lung cancer) and CaCo2 (colon cancer) cell lines was screened. Three tested compounds 4b, 4c and 4f showed promising activity.
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Cite this article as:
Abdel Hafez A. Naglaa, Hassaneen M.E. Huwaida , Farghaly A. Thoraya *, Riyadh M. Sayed and Elzahabi S.A. Heba , Synthesis of New Bis-Spiropyrazoles as Antitumor Agents under Ultrasound Irradiation, Mini-Reviews in Medicinal Chemistry 2018; 18 (7) . https://dx.doi.org/10.2174/1389557517666170912170027
DOI https://dx.doi.org/10.2174/1389557517666170912170027 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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