Abstract
Background: Propofol, a widely used intravenous anesthetic agent, is traditionally applied for sedation and general anesthesia.
Explanation: Recent attention has been drawn to explore the effect and mechanisms of propofol against cancer progression in vitro and in vivo. Specifically, the proliferation-inhibiting and apoptosis-inducing properties of propofol in cancer have been studied. However, the underlying mechanisms remain unclear.
Conclusion: This review focused on the findings within the past ten years and aimed to provide a general overview of propofol's malignance-modulating properties and the potential molecular mechanisms.
Keywords: Propofol, anesthetic, general anesthesia, neoplasms, anti-cancer, malignance-modulating.
Anti-Cancer Agents in Medicinal Chemistry
Title:Novel Findings of Anti-cancer Property of Propofol
Volume: 18 Issue: 2
Author(s): Jiaqiang Wang, Chien-shan Cheng, Yan Lu, Xiaowei Ding, Minmin Zhu, Changhong Miao*Jiawei Chen*
Affiliation:
- Department of Oncology, Shanghai Medical College, Fudan University, No. 270 DongAn Road, Shanghai 200032,China
- Department of Oncology, Shanghai Medical College, Fudan University, No. 270 DongAn Road, Shanghai 200032,China
Keywords: Propofol, anesthetic, general anesthesia, neoplasms, anti-cancer, malignance-modulating.
Abstract: Background: Propofol, a widely used intravenous anesthetic agent, is traditionally applied for sedation and general anesthesia.
Explanation: Recent attention has been drawn to explore the effect and mechanisms of propofol against cancer progression in vitro and in vivo. Specifically, the proliferation-inhibiting and apoptosis-inducing properties of propofol in cancer have been studied. However, the underlying mechanisms remain unclear.
Conclusion: This review focused on the findings within the past ten years and aimed to provide a general overview of propofol's malignance-modulating properties and the potential molecular mechanisms.
Export Options
About this article
Cite this article as:
Wang Jiaqiang , Cheng Chien-shan , Lu Yan , Ding Xiaowei, Zhu Minmin , Miao Changhong *, Chen Jiawei *, Novel Findings of Anti-cancer Property of Propofol, Anti-Cancer Agents in Medicinal Chemistry 2018; 18 (2) . https://dx.doi.org/10.2174/1871520617666170912120327
DOI https://dx.doi.org/10.2174/1871520617666170912120327 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Interactions of the Aryl Hydrocarbon Receptor with Inflammatory Mediators:Beyond CYP1A Regulation
Current Drug Metabolism Neuropilin and Neuropilin Associated Molecules as New Molecular Targets in Pancreatic Adenocarcinoma
Anti-Cancer Agents in Medicinal Chemistry The Genetic Background of Cholesterol Gallstone Formation: An Inventory of Human Lithogenic Genes
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Nitrogen-Containing Heterocycles as Anticancer Agents: An Overview
Anti-Cancer Agents in Medicinal Chemistry Using Insights into Pim1 Structure to Design New Anticancer Drugs
Current Pharmaceutical Design Intestinal Targeting of Drugs: Rational Design Approaches and Challenges
Current Topics in Medicinal Chemistry The State-of-Art in Angiogenic Properties of Latex from Different Plant Species
Current Angiogenesis (Discontinued) TGF-Beta Signaling Manipulation as Potential Therapy for IBD
Current Drug Targets Regulation of miRNA Processing and miRNA Mediated Gene Repression in Cancer
MicroRNA Molecular Mechanisms of Cardiac Voltage-Gated Potassium Channelopathies
Current Pharmaceutical Design Adrenergic and V1-ergic Agonists/Antagonists Affecting Recovery from Brain Trauma in the Lund Project Act on Astrocytes
Current Signal Transduction Therapy Dysregulated Chemokine Signaling in Cystic Fibrosis Lung Disease: A Potential Therapeutic Target
Current Drug Targets Genetic Variants in Genes Involved in Mechanisms of Chemoresistance to Anticancer Drugs
Current Cancer Drug Targets Looking at Drug Resistance Mechanisms for Microtubule Interacting Drugs: Does TUBB3 Work?
Current Cancer Drug Targets Studies of p53 Tumor Suppression Activity in Mouse Models
Current Genomics Extracts of <i>Anogeissus leiocarpus and Dillenia indica</i> Inhibit the Growth of MCF-7 Breast Cancer and COV434 Granulosa Tumor Cells by Inducing Apoptosis and Autophagy
Current Bioactive Compounds An Overview of Promising Biomarkers in Cancer Screening and Detection
Current Cancer Drug Targets Using Pharmacogenomic Tumor Profiling to Identify Biomarkers of 5-fluorouracil Response in Colorectal Cancer
Current Pharmacogenomics Nanocarriers in Improved Heparin Delivery: Recent Updates
Current Pharmaceutical Design The Application of Natural Products in Cancer Therapy by Targeting Apoptosis Pathways
Current Drug Metabolism