Abstract
Background: Thiazole is one of the leading heterocyclic five-member ring compounds that contain nitrogen and sulphur atom. Many natural and/or synthetic compounds contain thiazole as an essential moiety and possess diverse therapeutic activities. The thiazole ring was modified at different positions to generate new molecules with potent antibacterial activities. Thus, the present review enumerates the antibacterial importance of thiazole and its derivatives.
Method: The mining of literature has been performed using different database which includes only peer-reviewed journals. The quality of retrieved papers was appraised using standard tools. Moreover, the significant papers were described in detail to focus on thiazole derivatives showing considerable antibacterial activity.
Result: The present review describes the chemistry, SAR (Structure Activity Relationship) studies and antibacterial importance of thiazole with different synthetic procedures.
Conclusion: This particular study certainly benefits the researchers interested in exploiting the antibacterial activity of thiazoles in search of novel agents.
Keywords: Thiazole, chemistry, synthesis, antibacterial activity, DNA gyrase, derivatives.
Current Drug Discovery Technologies
Title:Review on Synthetic Chemistry and Antibacterial Importance of Thiazole Derivatives
Volume: 15 Issue: 3
Author(s): Ankita Kashyap, Nayana Adhikari, Arpita Das, Anshul Shakya, Surajit Kumar Ghosh, Udaya Pratap Singh and Hans Raj Bhat*
Affiliation:
- Department of Pharmaceutical Sciences, School of Science and Engineering, Dibrugarh University, Dibrugarh - 786 004, Assam,India
Keywords: Thiazole, chemistry, synthesis, antibacterial activity, DNA gyrase, derivatives.
Abstract: Background: Thiazole is one of the leading heterocyclic five-member ring compounds that contain nitrogen and sulphur atom. Many natural and/or synthetic compounds contain thiazole as an essential moiety and possess diverse therapeutic activities. The thiazole ring was modified at different positions to generate new molecules with potent antibacterial activities. Thus, the present review enumerates the antibacterial importance of thiazole and its derivatives.
Method: The mining of literature has been performed using different database which includes only peer-reviewed journals. The quality of retrieved papers was appraised using standard tools. Moreover, the significant papers were described in detail to focus on thiazole derivatives showing considerable antibacterial activity.
Result: The present review describes the chemistry, SAR (Structure Activity Relationship) studies and antibacterial importance of thiazole with different synthetic procedures.
Conclusion: This particular study certainly benefits the researchers interested in exploiting the antibacterial activity of thiazoles in search of novel agents.
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Cite this article as:
Kashyap Ankita , Adhikari Nayana , Das Arpita, Shakya Anshul , Ghosh Kumar Surajit, Singh Pratap Udaya and Bhat Raj Hans*, Review on Synthetic Chemistry and Antibacterial Importance of Thiazole Derivatives, Current Drug Discovery Technologies 2018; 15 (3) . https://dx.doi.org/10.2174/1570163814666170911144036
DOI https://dx.doi.org/10.2174/1570163814666170911144036 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
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