Abstract
Urotensin II (UT II) is an important factor of cellular homeostasis. This regulatory peptide is involved in the pathophysiology of many disorders. For example, it plays an important role in the pathogenesis of acute and chronic diseases, stressful and adaptive reactions of the body, in the development of cardiovascular pathologies, metabolic syndrome, inflammation, liver cirrhosis, renal failure, diabetic nephropathy, reproductive dysfunction, progression of psychosomatic, psychoendocrinal and psychiatric disorders. In this concern, the involvement of UT II in the pathophysiology of many processes determines the perspectives for the development of blockers of urotensin receptors for the treatment of the aforementioned diseases. It is important that even today this kind of perspective is feasible due to the synthesis of a series of GPR14 blockers. The objective of this review is to discuss current molecular mechanisms of biological activity, regulatory functions of UT II, its role in the pathogenesis of different nosologies, as well as analysis of the possible routes of exposure to GPR14 as potential therapeutic targets.
Keywords: Urotensin II, regulatory peptides, molecular targets of Urotensin II in cardiovascular, nervous, hormonal systems, stress, kidney, sexual function, cancer, G-protein-coupled receptors; drug design.
Current Protein & Peptide Science
Title:Urotensin II: Molecular Mechanisms of Biological Activity
Volume: 19 Issue: 9
Author(s): Andrey A. Svistunov, Vadim V. Tarasov, Svetlana A. Shakhmardanova, Susanna S. Sologova, Ekaterina T. Bagaturiya, Vladimir N. Chubarev, Pavel A. Galenko-Yaroshevsky, Marco Fidel Avila-Rodriguez, George E. Barreto and Gjumrakch Aliev*
Affiliation:
- GALLY International Biomedical Research Consulting LLC., 7733, Louis Pasteur, Drive, #330, San Antonio, TX, 78229,United States
Keywords: Urotensin II, regulatory peptides, molecular targets of Urotensin II in cardiovascular, nervous, hormonal systems, stress, kidney, sexual function, cancer, G-protein-coupled receptors; drug design.
Abstract: Urotensin II (UT II) is an important factor of cellular homeostasis. This regulatory peptide is involved in the pathophysiology of many disorders. For example, it plays an important role in the pathogenesis of acute and chronic diseases, stressful and adaptive reactions of the body, in the development of cardiovascular pathologies, metabolic syndrome, inflammation, liver cirrhosis, renal failure, diabetic nephropathy, reproductive dysfunction, progression of psychosomatic, psychoendocrinal and psychiatric disorders. In this concern, the involvement of UT II in the pathophysiology of many processes determines the perspectives for the development of blockers of urotensin receptors for the treatment of the aforementioned diseases. It is important that even today this kind of perspective is feasible due to the synthesis of a series of GPR14 blockers. The objective of this review is to discuss current molecular mechanisms of biological activity, regulatory functions of UT II, its role in the pathogenesis of different nosologies, as well as analysis of the possible routes of exposure to GPR14 as potential therapeutic targets.
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Cite this article as:
Svistunov A. Andrey, Tarasov V. Vadim, Shakhmardanova A. Svetlana, Sologova S. Susanna , Bagaturiya T. Ekaterina, Chubarev N. Vladimir , Galenko-Yaroshevsky A. Pavel , Avila-Rodriguez Fidel Marco , Barreto E. George and Aliev Gjumrakch *, Urotensin II: Molecular Mechanisms of Biological Activity, Current Protein & Peptide Science 2018; 19 (9) . https://dx.doi.org/10.2174/1389203718666170829162335
DOI https://dx.doi.org/10.2174/1389203718666170829162335 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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