Microwave-promoted Synthesis of S-substituted Quinazoline Derivatives using 1,4-dihydroquinazoline-2-thiol

Title:Microwave-promoted Synthesis of S-substituted Quinazoline Derivatives using 1,4-dihydroquinazoline-2-thiol

Volume: 15 Issue: 6

Author(s): Satya Karuna Pulakhandam, Naresh Kumar Katari*Ravi Prakash Reddy Manda

Affiliation:

• Department of Chemistry, GITAM School of Technology, GITAM University, HTP Campus, Rudraram, Medak, Telangana 502 329,India

Keywords: Chan-Lam coupling, quinazoline, boronic acid, microwave irradiation, copper acetate, one-pot reactions.

Abstract: A novel, rapid and efficient microwave-assisted synthesis of S-substituted quinazoline derivatives was obtained using 1,4-dihydroquinazoline-2-thiol and various boronic acids with copper catalyst in one-pot reactions. The versatility of the synthetic protocol with various boronic acids and the optimization processes of the microwave irradiation conditions including temperature, solvent, and reaction time were demonstrated.

Cite this article as:

Pulakhandam Karuna Satya , Katari Kumar Naresh *, Reddy Manda Prakash Ravi , Microwave-promoted Synthesis of S-substituted Quinazoline Derivatives using 1,4-dihydroquinazoline-2-thiol, Letters in Drug Design & Discovery 2018; 15 (6) . https://dx.doi.org/10.2174/1570180814666170823160851