A Novel Approach for Substitution of Sulfonate Group by (1H)-imidazole moiety: An Application for Synthesis of Novel Benzyl Imidazolyl carbamates

Title:A Novel Approach for Substitution of Sulfonate Group by (1H)-imidazole moiety: An Application for Synthesis of Novel Benzyl Imidazolyl carbamates

Volume: 15 Issue: 7

Author(s): Vijaya Durga Thripuram, Hari Babu Bollikolla*, Siva Nagi Reddy Mule, Sailaja Kumari Battula and Vasu Babu Ala

Affiliation:

• Department of Chemistry, University College of Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur - 522510, A.P,India

Keywords: α-amido sulphones, benzyl (imidazolyl) (aryl) methyl carbamate, Hexamethylphosphoramide, t-BuLi, imidazole, imidazolyl carbamate.

Abstract: An efficient and convenient substitution protocol was developed for the synthesis of novel benzyl (1-methyl-1H-imidazol-5-yl) (aryl) methyl carbamate derivatives from α-amido sulphones with a solution 5-bromo-1-methyl-(1H)-imidazole in THF under Hexamethylphosphoramide (HMPA) and t-BuLi medium at -78°C to room temperature. The reactions were monitored with TLC for about 3-4 h. The yields obtained were also considerably good.

Cite this article as:

Thripuram Durga Vijaya , Bollikolla Babu Hari *, Reddy Mule Nagi Siva , Battula Kumari Sailaja and Ala Babu Vasu, A Novel Approach for Substitution of Sulfonate Group by (1H)-imidazole moiety: An Application for Synthesis of Novel Benzyl Imidazolyl carbamates, Letters in Organic Chemistry 2018; 15 (7) . https://dx.doi.org/10.2174/1570178614666170811121704