Abstract
Background & Objective: Brain areas of functional activation during emotional stimuli and their correlations with affective temperaments evaluated using Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS-A) and hopelessness levels assessed with the Beck Hopelessness Scale (BHS) have been investigated.
Method: Brain activity in response to emotional stimuli was examined by Nuclear Magnetic Resonance Blood Oxygen Level Dependent (NMR BOLD) signal. Seventeen subjects (mean age ± SD = 57 ± 12), diagnosed with major affective disorders and eighteen healthy controls (HC) (mean age ± SD = 50±11) participated in this study. Higher functional activation of the left amygdala and cingulated gyrus was found in subjects with affective disorders; whereas, the right amygdala was mostly activated in the HC group. Higher BHS scores were associated with reduced BOLD activation throughout the primary somatosensorial cortex and left post-central gyrus.
Conclusion: Conversely, increased BOLD activation throughout the parietal superior lobule and right anterior intraperietal sulcus, occipital cortex, and left optical radiation, right insular cortex, right frontal superior gyrus was correlated with higher BHS total scores. Future studies should investigate the nature of the associations among brain activation, suicide risk, and affective temperaments in larger samples.
Keywords: Affective temperaments, fMRI, hopelessness, major affective disorders, neural correlates, suicide risk.
CNS & Neurological Disorders - Drug Targets
Title:Neural Correlates in Patients with Major Affective Disorders: An fMRI Study
Volume: 16 Issue: 8
Author(s): Gianluca Serafini, Maurizio Pompili*, Andrea Romano, Denise Erbuto, Dorian A. Lamis, Marta Moraschi, Maria Camilla Rossi Espagnet, Mario Amore, Paolo Girardi and Alessandro Bozzao
Affiliation:
- Department of Neurosciences, Suicide Prevention Center, Sant'Andrea Hospital, University of Rome, Rome,Italy
Keywords: Affective temperaments, fMRI, hopelessness, major affective disorders, neural correlates, suicide risk.
Abstract: Background & Objective: Brain areas of functional activation during emotional stimuli and their correlations with affective temperaments evaluated using Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS-A) and hopelessness levels assessed with the Beck Hopelessness Scale (BHS) have been investigated.
Method: Brain activity in response to emotional stimuli was examined by Nuclear Magnetic Resonance Blood Oxygen Level Dependent (NMR BOLD) signal. Seventeen subjects (mean age ± SD = 57 ± 12), diagnosed with major affective disorders and eighteen healthy controls (HC) (mean age ± SD = 50±11) participated in this study. Higher functional activation of the left amygdala and cingulated gyrus was found in subjects with affective disorders; whereas, the right amygdala was mostly activated in the HC group. Higher BHS scores were associated with reduced BOLD activation throughout the primary somatosensorial cortex and left post-central gyrus.
Conclusion: Conversely, increased BOLD activation throughout the parietal superior lobule and right anterior intraperietal sulcus, occipital cortex, and left optical radiation, right insular cortex, right frontal superior gyrus was correlated with higher BHS total scores. Future studies should investigate the nature of the associations among brain activation, suicide risk, and affective temperaments in larger samples.
Export Options
About this article
Cite this article as:
Serafini Gianluca , Pompili Maurizio *, Romano Andrea , Erbuto Denise , Lamis A. Dorian , Moraschi Marta , Rossi Espagnet Camilla Maria, Amore Mario , Girardi Paolo and Bozzao Alessandro , Neural Correlates in Patients with Major Affective Disorders: An fMRI Study, CNS & Neurological Disorders - Drug Targets 2017; 16 (8) . https://dx.doi.org/10.2174/1871527316666170803143006
DOI https://dx.doi.org/10.2174/1871527316666170803143006 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Design and In Vitro Evaluation of a Novel Vaginal Drug Delivery System Based on Gelucire
Current Drug Delivery Conformational Changes Preceding Amyloid-Fibril Formation of Amyloid- Beta, Prion Protein and Stefin B; Parallels in pH Dependence
Medicinal Chemistry Reviews - Online (Discontinued) Association of Genetic Polymorphisms of CYP2C9 and VKORC1 with Bleeding Following Warfarin: A Case-Control Study
Current Clinical Pharmacology Increased Epileptiform EEG Activity and Decreased Seizure Threshold in Arctic APP Transgenic Mouse Model of Alzheimer’s Disease
Current Alzheimer Research Recent Progress in Syntheses and Biological Activities of Kainic Acid and its Derivatives
Current Organic Chemistry Antiepileptic Drugs in the Neurosurgical Intensive Care
Current Pharmaceutical Design L-Type Calcium Channels
Current Pharmaceutical Design Types of Voltage-Gated Calcium Channels: Molecular and Electrophysiological Views
Current Hypertension Reviews Bioactive N-Phenylimidazole Derivatives
Current Chemical Biology Reducing Gabaergic Inhibition Restores Cognitive Functions in a Mouse Model of Down Syndrome
CNS & Neurological Disorders - Drug Targets Clinical Features of Scleroderma-Like Disorders: A Challenge for the Rheumatologist
Current Rheumatology Reviews Histamine H3 Receptor Ligands in the Group of (Homo)piperazine Derivatives
Current Medicinal Chemistry The Autism Candidate Gene Neurobeachin Encodes a Scaffolding Protein Implicated in Membrane Trafficking and Signaling
Current Molecular Medicine The Role of Calcium Stores in Apoptosis and Autophagy
Current Molecular Medicine Application of Contemporary Neuroproteomic Techniques in Unravelling Neurological Disorders
Current Protein & Peptide Science Editorial [Hot Topic: Adult Stem Cells and Tissue Engineering in Central Nervous System Regenerative Medicine (Guest Editor: Antonio J. Salgado)]
Current Stem Cell Research & Therapy Importance of P-gp PET Imaging in Pharmacology
Current Pharmaceutical Design Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders
Current Molecular Medicine Comparision of Clinical Findings with CTPA Findings in Pulmonary Embolism
Current Medical Imaging The Relationship Between Cleft Lip, Maxillary Hypoplasia, Hypoxia and Phenytoin
Current Pharmaceutical Design