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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Review Article

The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment

Author(s): Dayun Yan*, Jonathan H. Sherman and Michael Keidar*

Volume 18, Issue 6, 2018

Page: [769 - 775] Pages: 7

DOI: 10.2174/1871520617666170731115233

Price: $65

Abstract

Background: Over the past five years, the cold atmospheric plasma-activated solutions (PAS) have shown their promissing application in cancer treatment. Similar as the common direct cold plasma treatment, PAS shows a selective anti-cancer capacity in vitro and in vivo. However, different from the direct cold atmospheric plasma (CAP) treatment, PAS can be stored for a long time and can be used without dependence on a CAP device. The research on PAS is gradually becoming a hot topic in plasma medicine.

Objectives: In this review, we gave a concise but comprehensive summary on key topics about PAS including the development, current status, as well as the main conclusions about the anti-cancer mechanism achieved in past years. The approaches to make strong and stable PAS are also summarized.

Keywords: Plasma, cold atmospheric plasma, cancer cells, cancer treatment, reactive nitrogen species, reactive oxygen species.

Graphical Abstract

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