Ventricular Extrasystoles after First Dose of Sofosbuvir in a Patient Treated with Propranolol but not with Amiodarone: A Case Report

Title:Ventricular Extrasystoles after First Dose of Sofosbuvir in a Patient Treated with Propranolol but not with Amiodarone: A Case Report

Volume: 12 Issue: 3

Author(s): Samir Rouabhia*, Sabah Baghazza, Hamza Sadouki, Sihem Djezzar, Rafik Bencherif, Rofia Guehimeche, Mourad Sadelaoud, Djamel Mallem and Karima Chaabna

Affiliation:

• Department of Internal Medicine, University Hospital Center Touhami Benflis, Batna 05000, Algeria and Department of Medicine, University Batna 2, Batna 05000,Algeria

Keywords: Cardiac arrhythmia, drug interaction, extrasystole, Hepatitis C, propranolol, sofosbuvir.

Abstract: Background: Sofosbuvir is a direct-acting antiviral drug used to treat chronic hepatitis C infection. In 2015, Gilead Sciences, the manufacturer of sofosbuvir, warned that bradycardia could occur when sofosbuvir is administered in combination with amiodarone. Interestingly, among the reported cases of patients with sofosbuvir and amiodarone related bradycardia, some of them were also treated with propranolol.

Objective: We herein report a case of ventricular extrasystoles within three hours after the coadministration of sofosbuvir-containing regimen with propranolol. This patient had never been treated with amiodarone. After the sofosbuvir-containing regimen was stopped, ventricular extrasystoles disappeared within 24 hours. This observation suggests that the association of sofosbuvir with propranolol may have a role in the emergence of cardiac arrhythmia.

Conclusion: Patients treated with amiodarone and/or propranolol should be continuously monitored within the early hours following the initiation of sofosbuvir.

Cite this article as:

Rouabhia Samir *, Baghazza Sabah , Sadouki Hamza, Djezzar Sihem , Bencherif Rafik, Guehimeche Rofia , Sadelaoud Mourad, Mallem Djamel and Chaabna Karima, Ventricular Extrasystoles after First Dose of Sofosbuvir in a Patient Treated with Propranolol but not with Amiodarone: A Case Report, Reviews on Recent Clinical Trials 2017; 12 (3) . https://dx.doi.org/10.2174/1574887112666170725132044