Abstract
Free radicals are important mediators for cell toxicity and pathogenesis of diseases. Reactive oxygen species (ROS) have been generated broadly in inflammatory diseases including autoimmune diseases. ROS have been not only associated with the initiation and progression of the autoimmune response but also in amplification and exploring to novel epitopes, through the unveiling of antigenic determinants. This review explores the involvement of ROS in the pathophysiology of non-organ specific autoimmune diseases like systemic lupus erythematosus (SLE). The modification of human serum albumin through hydroxyl radical is thought to be responsible for the induction of autoantibodies against modified human serum albumin. In the light of overwhelming evidence suggesting the association with oxidative damage in autoimmunity, the administration of antioxidants could be a viable alternative for the neutralization of free radicals that are involved in eliciting autoimmune disease. In this review, we have discussed their pro-oxidant as well anti-oxidant properties which are capable of differentially modulating the autoimmune response.
Keywords: Human serum albumin, ROS, SLE, hydroxy radicals (●OH), hydrogen peroxide (H2O2).
Current Protein & Peptide Science
Title:Impact of Hydroxyl Radical Modified-Human Serum Albumin Autoantigens in Systemic Lupus Erythematosus
Volume: 19 Issue: 9
Author(s): Md. Asad Khan*, Khursheed Alam, Ghulam Md Ashraf and M. Moshahid A. Rizvi
Affiliation:
- Department of Biosciences, Jamia Millia Islamia, New Delhi,India
Keywords: Human serum albumin, ROS, SLE, hydroxy radicals (●OH), hydrogen peroxide (H2O2).
Abstract: Free radicals are important mediators for cell toxicity and pathogenesis of diseases. Reactive oxygen species (ROS) have been generated broadly in inflammatory diseases including autoimmune diseases. ROS have been not only associated with the initiation and progression of the autoimmune response but also in amplification and exploring to novel epitopes, through the unveiling of antigenic determinants. This review explores the involvement of ROS in the pathophysiology of non-organ specific autoimmune diseases like systemic lupus erythematosus (SLE). The modification of human serum albumin through hydroxyl radical is thought to be responsible for the induction of autoantibodies against modified human serum albumin. In the light of overwhelming evidence suggesting the association with oxidative damage in autoimmunity, the administration of antioxidants could be a viable alternative for the neutralization of free radicals that are involved in eliciting autoimmune disease. In this review, we have discussed their pro-oxidant as well anti-oxidant properties which are capable of differentially modulating the autoimmune response.
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Cite this article as:
Khan Asad Md. *, Alam Khursheed , Ashraf Md Ghulam and Rizvi Moshahid A. M. , Impact of Hydroxyl Radical Modified-Human Serum Albumin Autoantigens in Systemic Lupus Erythematosus, Current Protein & Peptide Science 2018; 19 (9) . https://dx.doi.org/10.2174/1389203718666170725115319
DOI https://dx.doi.org/10.2174/1389203718666170725115319 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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