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Current Microwave Chemistry

Editor-in-Chief

ISSN (Print): 2213-3356
ISSN (Online): 2213-3364

Research Article

Ligand Free Microwave Assisted Copper-Catalyzed Convenient Synthesis of Substituted Tertiary Amines from Nitroarenes

Author(s): Kshipra S. Karnik, Aniket P. Sarkate, Sushilkumar S. Bahekar and Pravin S. Wakte*

Volume 4, Issue 3, 2017

Page: [256 - 261] Pages: 6

DOI: 10.2174/2213335604666170718164148

Price: $65

Abstract

Background: A ligand free, microwave assisted, copper catalyzed synthetic procedure for substituted tertiary amines has been developed by using nitroarenes and secondary amines.

Methods: In the synthetic method, the targeted substituted tertiary amines were synthesized with the help of the microwave by reacting nitroarenes and substituted secondary amines in the presence of copper, potassium carbonate and methanol.

Results: All substituted tertiary amines were obtained in good yields (88-94%) with the help of a microwave technique (07-12 min) in less time. The protocol adopted was ligand free.

Conclusion: Microwave assisted technique will be a useful alternative protocol for the preparation of a diverse range of substituted tertiary amines.

Keywords: Catalyst, copper, ligand free, microwave, nitroarenes, tertiary amines.

Graphical Abstract

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