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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Pharmacological Treatment of Vagal Hyperactivity, a Rare but Potentially Fatal Cause of Sudden Cardiac Death

Author(s): Bassareo Pier Paolo*, Cocco Daniele, Bassareo Valentina, Bandino Stefano and Mercuro Giuseppe

Volume 18, Issue 6, 2018

Page: [483 - 489] Pages: 7

DOI: 10.2174/1389557517666170707102040

Price: $65

Abstract

Vasovagal reaction, resulting in bradycardia and/or hypotension in response to a number of stimuli, is usually self-limiting, but potentially life-threatening exceptions have been described. Pharmacological treatment of proven efficacy is still lacking and the administered compounds are often chosen on the basis of either case reports or outdated small studies with a short-term follow up. In refractory cases, pacemaker implantation may be considered, although no responder patients represent a severe challenge for clinicians. The aim of this review is to examine the state of the art about this controversial issue.

Keywords: Blood pressure, bradycardia, hyperactivity, reflex vagal hypertonia, sudden death, therapy.


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