Abstract
Neutrophils are the most abundant population of white blood cells in the human circulation playing a critical role in inflammation and in host defense against microbial infections. In recent years there has been growing interest in understanding the role the tumor microenvironment plays in tumor growth and progression. In this context, the role neutrophils play has been a matter of debate as neutrophils were shown to possess both tumor promoting and tumor limiting properties. These conflicting observations stem from differences in how neutrophils respond to environmental cues as well as from the existence of distinct tumor-promoting and tumor-limiting neutrophil populations. Here, we review general aspects of neutrophil biology and the favorable functions of neutrophils in the primary tumor and the pre-metastatic microenvironment. We further discuss the mechanisms neutrophils employ to limit tumor progression and highlight the aspects of neutrophil biology that may be targeted in future neutrophil-based cancer immunotherapies.
Keywords: Neutrophils, cancer, metastasis, inflammation, neutrophils, tumor.
Current Pharmaceutical Design
Title:Always Look On the Bright Side: Anti-Tumor Functions of Neutrophils
Volume: 23 Issue: 32
Author(s): Sandra Vols, Ronit Vogt Sionov and Zvi Granot*
Affiliation:
- Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, Hebrew University Medical School, 91120, Jerusalem,Israel
Keywords: Neutrophils, cancer, metastasis, inflammation, neutrophils, tumor.
Abstract: Neutrophils are the most abundant population of white blood cells in the human circulation playing a critical role in inflammation and in host defense against microbial infections. In recent years there has been growing interest in understanding the role the tumor microenvironment plays in tumor growth and progression. In this context, the role neutrophils play has been a matter of debate as neutrophils were shown to possess both tumor promoting and tumor limiting properties. These conflicting observations stem from differences in how neutrophils respond to environmental cues as well as from the existence of distinct tumor-promoting and tumor-limiting neutrophil populations. Here, we review general aspects of neutrophil biology and the favorable functions of neutrophils in the primary tumor and the pre-metastatic microenvironment. We further discuss the mechanisms neutrophils employ to limit tumor progression and highlight the aspects of neutrophil biology that may be targeted in future neutrophil-based cancer immunotherapies.
Export Options
About this article
Cite this article as:
Vols Sandra, Sionov Vogt Ronit and Granot Zvi*, Always Look On the Bright Side: Anti-Tumor Functions of Neutrophils, Current Pharmaceutical Design 2017; 23 (32) . https://dx.doi.org/10.2174/1381612823666170704125420
DOI https://dx.doi.org/10.2174/1381612823666170704125420 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements