Abstract
Background: Diabetes Mellitus (DM) is a disorder of glucose metabolism marked by hyperglycemia, glycosuria, hyperlipidemia, negative nitrogen balance and ketonaemia. DM is a major healthcare problems today and its treatment costs billions of dollars worldwide annually. The cases of diabetes have increased rapidly in recent years throughout the world. Currently, for the management of Type-1 Diabetes Mellitus (TIDM), Multiple Daily Insulin (MDI) injections is the most popular treatment. Oral administration of insulin is the most suitable and attractive as compared to subcutaneous route but unfortunately cannot be utilized for the administration of peptides and proteins due to poor epithelial permeability and enzymatic degradation within the gastrointestinal tract. Since many years, extensive research has been carried out to explore the potential ways of insulin administration based on novel methods such as liposome, microsphere, nanoparticle, mouth dissolving strips, sprays exploiting oral and pulmonary route. These next generation efficient therapies for T1DM may help to improve the quality of life of diabetic patients especially in Insulin Dependent Diabetes Mellitus (IDDM).
Conclusion: This review emphasizes on the most recent progress made in the development of oral insulin delivery formulations, and focuses on key lessons and implications from studies undertaken till date with the oral insulin formulations. Further, this review analyzes effectiveness of the advancements, applications and limitations of the technologies in delivering insulin to the targeted site through oral administration.
Keywords: Diabetes mellitus, oral insulin, particulate carriers, hydrogels, buccal insulin, IDDM.
Current Diabetes Reviews
Title:Oral Insulin: Myth or Reality
Volume: 14 Issue: 6
Author(s): Vikas Kumar, Ishwari Choudhry, Ankit Namdev, Sumit Mishra, Sourabh Soni, Pooja Hurkat*, Ashish Jain and Dharmendra Jain*
Affiliation:
- Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, 470003, (MP),India
- Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, 470003, (MP),India
Keywords: Diabetes mellitus, oral insulin, particulate carriers, hydrogels, buccal insulin, IDDM.
Abstract: Background: Diabetes Mellitus (DM) is a disorder of glucose metabolism marked by hyperglycemia, glycosuria, hyperlipidemia, negative nitrogen balance and ketonaemia. DM is a major healthcare problems today and its treatment costs billions of dollars worldwide annually. The cases of diabetes have increased rapidly in recent years throughout the world. Currently, for the management of Type-1 Diabetes Mellitus (TIDM), Multiple Daily Insulin (MDI) injections is the most popular treatment. Oral administration of insulin is the most suitable and attractive as compared to subcutaneous route but unfortunately cannot be utilized for the administration of peptides and proteins due to poor epithelial permeability and enzymatic degradation within the gastrointestinal tract. Since many years, extensive research has been carried out to explore the potential ways of insulin administration based on novel methods such as liposome, microsphere, nanoparticle, mouth dissolving strips, sprays exploiting oral and pulmonary route. These next generation efficient therapies for T1DM may help to improve the quality of life of diabetic patients especially in Insulin Dependent Diabetes Mellitus (IDDM).
Conclusion: This review emphasizes on the most recent progress made in the development of oral insulin delivery formulations, and focuses on key lessons and implications from studies undertaken till date with the oral insulin formulations. Further, this review analyzes effectiveness of the advancements, applications and limitations of the technologies in delivering insulin to the targeted site through oral administration.
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Cite this article as:
Kumar Vikas, Choudhry Ishwari, Namdev Ankit , Mishra Sumit , Soni Sourabh , Hurkat Pooja *, Jain Ashish and Jain Dharmendra *, Oral Insulin: Myth or Reality, Current Diabetes Reviews 2018; 14 (6) . https://dx.doi.org/10.2174/1573399813666170621122742
DOI https://dx.doi.org/10.2174/1573399813666170621122742 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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