Abstract
Background: A key goal of mining single nucleotide polymorphism data of complex diseases (CD) is to build models that provide fundamental insight into genetic variations of CD. Therefore, we can predict disease risk and clinical outcomes and ultimately understand the development and progress mechanism of CD. As the technologies of omics data generation and computer science, the reductionist paradigm of genome wide association study becomes less prevalent.
Conclusion: In this review, we summarize the different strategies for boosting the power of association study, which include data quality improvement, high-performance computing platform and advanced computational method. Using these complementary approaches, the fundamental mechanism of genomic variations affecting occurrence and development of CD may be uncovered.
Keywords: Complex diseases, epistasis, systems biology, cloud computing, data integration.
Current Bioinformatics
Title:Methods for Mining Single Nucleotide Polymorphism Data of Complex Diseases
Volume: 13 Issue: 4
Author(s): Xiong Li*
Affiliation:
- School of Software, East China Jiaotong University, Nanchang 330013,China
Keywords: Complex diseases, epistasis, systems biology, cloud computing, data integration.
Abstract: Background: A key goal of mining single nucleotide polymorphism data of complex diseases (CD) is to build models that provide fundamental insight into genetic variations of CD. Therefore, we can predict disease risk and clinical outcomes and ultimately understand the development and progress mechanism of CD. As the technologies of omics data generation and computer science, the reductionist paradigm of genome wide association study becomes less prevalent.
Conclusion: In this review, we summarize the different strategies for boosting the power of association study, which include data quality improvement, high-performance computing platform and advanced computational method. Using these complementary approaches, the fundamental mechanism of genomic variations affecting occurrence and development of CD may be uncovered.
Export Options
About this article
Cite this article as:
Li Xiong *, Methods for Mining Single Nucleotide Polymorphism Data of Complex Diseases, Current Bioinformatics 2018; 13 (4) . https://dx.doi.org/10.2174/1574893612666170619083537
DOI https://dx.doi.org/10.2174/1574893612666170619083537 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Discrimination of Active and Weakly Active Human BACE1 Inhibitors Using Self-Organizing Map and Support Vector Machine
Combinatorial Chemistry & High Throughput Screening Conotoxins: Structure, Therapeutic Potential and Pharmacological Applications
Current Pharmaceutical Design Aging process, cognitive decline and Alzheimer`s disease: can strength training modulate these responses?
CNS & Neurological Disorders - Drug Targets LECTURES
Adolescent Psychiatry The ATP-Binding Cassette Transporter-2 (ABCA2) Increases Endogenous Amyloid Precursor Protein Expression and Abeta Fragment Generation
Current Alzheimer Research Inhibition of Bacterial Carbonic Anhydrases and Zinc Proteases: From Orphan Targets to Innovative New Antibiotic Drugs
Current Medicinal Chemistry Cardiovascular Risk Factors, Metabolic Complications, & the Natural Course of CKD in Children
Current Hypertension Reviews Metal-Score as a Potential Non-Invasive Diagnostic Test for Alzheimer’s Disease
Current Alzheimer Research Hemodialysis Membranes for Acute and Chronic Renal Insufficiency
Current Neurovascular Research Is Dopamine Neurotransmission Altered in Prodromal Schizophrenia? A Review of the Evidence
Current Pharmaceutical Design Formulation and Evaluation of Neuroactive Drug Loaded Chitosan Nanoparticle for Nose to Brain Delivery: In-vitro Characterization and In-vivo Behavior Study
Current Drug Delivery Subject Index to Volume 4
Current Drug Targets - Cardiovascular & Hematological Disorders The Role of Beverage Congeners in Hangover and Other Residual Effects of Alcohol Intoxication: A Review
Current Drug Abuse Reviews APOE Genotypes and Brain Imaging Classes in Normal Cognition, Mild Cognitive Impairment, and Alzheimer’s Disease: A Longitudinal Study
Current Alzheimer Research Melatonin Ameliorates BPA Induced Oxidative Stress in Human Red Blood Cells: An <i>In vitro</i> Study
Endocrine, Metabolic & Immune Disorders - Drug Targets Mechanisms of the Beneficial Actions of Ischemic Preconditioning on Subcellular Remodeling in Ischemic-Reperfused Heart
Current Cardiology Reviews Novel Agents, Combinations and Sequences for the Treatment of Advanced Renal Cell Carcinoma: When is the Revolution Coming?
Current Cancer Drug Targets Pharmacotherapy and the Psychobiological Model of Personality: Implications for DSM-5
Current Psychopharmacology Protein/ Hormone Based Nanoparticles as Carriers for Drugs Targeting Protein-Protein Interactions
Current Topics in Medicinal Chemistry Inter- and Intrahemispheric Coherence of Electroencephalography Peaks in Children with Autism
Neuroscience and Biomedical Engineering (Discontinued)