Abstract
Sarcopenia, the progressive and generalized loss of skeletal muscle mass and strength/function associated with aging, increases the risk of a vast array of adverse health outcomes, including falls, morbidity, loss of independence, disability, and mortality. As such, sarcopenia poses a huge socioeconomic burden in developed countries. The development and implementation of effective interventions against sarcopenia are therefore a public health priority. A preliminary, fundamental step in such a process entails the agreement of researchers, healthcare professionals and policymakers around a unique operational definition of sarcopenia. This will facilitate the framing of a clear clinical entity to be incorporated in standard practice, the understanding of the underlying pathophysiology, and the identification of biological targets for drug development.
Keywords: Exercise, frailty, gait speed, muscle mass, muscle strength, operational definition, physical performance, protein.
Current Protein & Peptide Science
Title:Sarcopenia: An Overview on Current Definitions, Diagnosis and Treatment
Volume: 19 Issue: 7
Author(s): Francesco Landi*, Riccardo Calvani, Matteo Cesari, Matteo Tosato, Anna Maria Martone, Elena Ortolani, Giulia Savera, Sara Salini, Alex Sisto, Anna Picca and Emanuele Marzetti
Affiliation:
- Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart, Rome,Italy
Keywords: Exercise, frailty, gait speed, muscle mass, muscle strength, operational definition, physical performance, protein.
Abstract: Sarcopenia, the progressive and generalized loss of skeletal muscle mass and strength/function associated with aging, increases the risk of a vast array of adverse health outcomes, including falls, morbidity, loss of independence, disability, and mortality. As such, sarcopenia poses a huge socioeconomic burden in developed countries. The development and implementation of effective interventions against sarcopenia are therefore a public health priority. A preliminary, fundamental step in such a process entails the agreement of researchers, healthcare professionals and policymakers around a unique operational definition of sarcopenia. This will facilitate the framing of a clear clinical entity to be incorporated in standard practice, the understanding of the underlying pathophysiology, and the identification of biological targets for drug development.
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Cite this article as:
Landi Francesco *, Calvani Riccardo , Cesari Matteo , Tosato Matteo , Martone Maria Anna, Ortolani Elena , Savera Giulia , Salini Sara , Sisto Alex , Picca Anna and Marzetti Emanuele, Sarcopenia: An Overview on Current Definitions, Diagnosis and Treatment, Current Protein & Peptide Science 2018; 19 (7) . https://dx.doi.org/10.2174/1389203718666170607113459
DOI https://dx.doi.org/10.2174/1389203718666170607113459 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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