Abstract
Introduction: The ever-evolving field of gene therapy promises several innovative treatments for cancer. Advances in genetic modification of tumor cells and micro environment have led to the development of more effective therapeutic strategies with fewer side effects.
Materials & Methods: The development of effective delivery system challenges, remains. Non-viral vectors are interesting due to their bio-safety and their ability to transfer different types of nucleic acids. Examples of these techniques are the use of oligonucleoides, liposomes, nanoparticles, inorganic material, and engineered stem cells. Conclusion: In this review, we focus on recent advances in the intracellular delivery of DNA and siRNA to the cancer cells with emphasis on breast cancer.Keywords: Breast cancer, Non-viral delivery system, APTAMER, Gene therapy, DNA, RNA.
Current Gene Therapy
Title:Non-viral Delivery Systems for Breast Cancer Gene Therapy
Volume: 17 Issue: 2
Author(s): Golnaz Vaseghi, Laleh Rafiee and Shaghayegh Haghjooy Javanmard*
Affiliation:
- Applied Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan,Iran
Keywords: Breast cancer, Non-viral delivery system, APTAMER, Gene therapy, DNA, RNA.
Abstract: Introduction: The ever-evolving field of gene therapy promises several innovative treatments for cancer. Advances in genetic modification of tumor cells and micro environment have led to the development of more effective therapeutic strategies with fewer side effects.
Materials & Methods: The development of effective delivery system challenges, remains. Non-viral vectors are interesting due to their bio-safety and their ability to transfer different types of nucleic acids. Examples of these techniques are the use of oligonucleoides, liposomes, nanoparticles, inorganic material, and engineered stem cells. Conclusion: In this review, we focus on recent advances in the intracellular delivery of DNA and siRNA to the cancer cells with emphasis on breast cancer.Export Options
About this article
Cite this article as:
Vaseghi Golnaz, Rafiee Laleh and Javanmard Haghjooy Shaghayegh*, Non-viral Delivery Systems for Breast Cancer Gene Therapy, Current Gene Therapy 2017; 17 (2) . https://dx.doi.org/10.2174/1566523217666170606124131
DOI https://dx.doi.org/10.2174/1566523217666170606124131 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Transcriptome Analysis of mRNA in Uterine Leiomyoma Using Next-generation RNA Sequencing
Anti-Cancer Agents in Medicinal Chemistry Synthesis and In Vitro Biochemical Evaluation of a Series of Alkyl 6- Aminosulfonyl Naphthanoates as Potential Inhibitors of Human Placental Estrone Sulfatase (ES)
Letters in Drug Design & Discovery VEGF/VEGFR Pathway Inhibitors as Anti-Angiogenic Agents: Present and Future
Current Cancer Drug Targets Liposomes as Anticancer Therapeutic Drug Carrier’s Systems: More than a Tour de Force
Current Nanomedicine miRNAs Modulate the Dichotomy of Cisplatin Resistance or Sensitivity in Breast Cancer: An Update of Therapeutic Implications
Anti-Cancer Agents in Medicinal Chemistry Pharmacological Management of Chronic Obstructive Lung Disease (COPD). Focus on Mutations - Part 1
Current Medicinal Chemistry UPA and PAI-1 Analysis from Fixed Tissues – New Perspectives for a Known Set of Predictive Markers
Current Medicinal Chemistry Momordica balsamina: A Medicinal and Neutraceutical Plant for Health Care Management
Current Pharmaceutical Biotechnology Established and In-trial GPCR Families in Clinical Trials: A Review for Target Selection
Current Drug Targets Menopausal Transition and Chronic Diseases
Current Women`s Health Reviews Therapeutic Targeting of Chemokines with Monoclonal Antibodies
Current Immunology Reviews (Discontinued) Mammalian DNA (Cytosine-5) Methyltransferase Mechanisms and RNA-Mediated Inhibition for Future Therapies
Epigenetic Diagnosis & Therapy (Discontinued) Pharmacophore Searching of Benzofuran Derivatives for Selective CYP19 Aromatase Inhibition
Letters in Drug Design & Discovery Clinical Pharmacogenetics and Potential Application in Personalized Medicine
Current Drug Metabolism The Conduct of Drug Metabolism Studies Considered Good Practice (I): Analytical Systems and In Vivo Studies
Current Drug Metabolism Folic Acid Conjugated Chitosan Nanoparticles for Tumor Targeting of Therapeutic and Imaging Agents
Pharmaceutical Nanotechnology Carbonic Anhydrase IX as a Target for Designing Novel Anticancer Drugs
Current Medicinal Chemistry Recent Clinical Aspects of Hyperprolactinemia Induced by Antipsychotics
Reviews on Recent Clinical Trials Meet Our Editorial Board Member
Letters in Drug Design & Discovery Nutrient-By-Genotype Interactions and Personalized Diet: What Can We Learn From Drosophila and Evolutionary Biology?
Current Pharmacogenomics and Personalized Medicine