Advantages and Limitations of Current Biomarker Research: From Experimental Research to Clinical Application

Title:Advantages and Limitations of Current Biomarker Research: From Experimental Research to Clinical Application

Volume: 18 Issue: 6

Author(s): Seung-Hyun Kim *, Christel Weiß , Ursula Hoffmann, Martin Borggrefe, Ibrahim Akin and Michael Behnes

Affiliation:

• First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim,Germany

Keywords: Cardiovascular disease, heart failure, acute coronary syndrome, biomarker, proteome, metabolome, micro-RNA.

Abstract: Background: Biomarkers are indispensable tools for screening, diagnosis, and prognosis in cardiovascular diseases and their clinical application increases steadily. As cardiovascular diseases include various pathophysiological processes, no single biomarker, even natriuretic peptides, can be regarded as ideal fulfilling all necessary criteria for a comprehensive diagnostic or prognostic assessment revealing optimal clinical application. Hence, multi-marker approaches using different biomarkers reflecting different pathophysiologies were highlighted recently. Advances in biomedical technologies expanded the spectrum of novel blood-derived biomarkers, such as micro-RNA (miRNA) or “omics”- data potentially providing a more advanced knowledge about pathogenesis of cardiovascular disease.

Cite this article as:

Kim Seung-Hyun *, Weiß Christel , Hoffmann Ursula, Borggrefe Martin , Akin Ibrahim and Behnes Michael , Advantages and Limitations of Current Biomarker Research: From Experimental Research to Clinical Application, Current Pharmaceutical Biotechnology 2017; 18 (6) . https://dx.doi.org/10.2174/1389201018666170601091205