Synthesis of New Symmetrical N, N'-Diacylhydrazines and 2-(1,2,3- Triazol-4-yl)-1,3,4-oxadiazoles

Title:Synthesis of New Symmetrical N, N'-Diacylhydrazines and 2-(1,2,3- Triazol-4-yl)-1,3,4-oxadiazoles

Volume: 14 Issue: 8

Author(s): Bakr F. Abdel-Wahab*, Mohammad Hayal Alotaibi and Gamal A. El-Hiti*

Affiliation:

• Applied Organic Chemistry Department, National Research Centre, Dokki, Giza,Egypt

• Cornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433,Saudi Arabia

Keywords: Symmetrical N, N'-diacylhydrazines, N-acylhydrazones, carbohydraides, 1, 3, 4-oxadiazoles, benzyldiene.

Abstract: Background: The aim of the current research was to synthesize novel symmetrical N,N'- diacylhydrazines through oxidation of acid carbohydrazide using ethyl 2-cyano-3-methoxyacrylate or 2-(methoxymethylene)malononitrile as organo-catalyst. Also, novel 2-(1,2,3-triazol-4-yl)-1,3,4- oxadiazoles from the reaction of acid carbohydrazides with various carboxylic acids in boiling phosphoryl chloride were synthesized.

Methods: Facile synthetic methods were used for the synthesis of target compounds using commercially available chemicals. Also, the structures of the products obtained were elucidated with the use of analytical and spectroscopic data along with the single x-ray crystal structures.

Results: A series of novel symmetrical N,N'-diacylhydrazines, 2-(1,2,3-triazol-4-yl)-1,3,4-oxadiazoles and aldehyde N-acylhydrazones, were synthesized in good yields using convenient and simple procedures.

Conclusion: New one-step synthetic procedures were introduced for the production of several symmetrical N,N'-diacylhydrazines and 2-(1,2,3-triazol-4-yl)-1,3,4-oxadiazoles in good yields from the corresponding acid hydrazides.

Cite this article as:

Abdel-Wahab F. Bakr *, Alotaibi Hayal Mohammad and El-Hiti A. Gamal *, Synthesis of New Symmetrical N, N'-Diacylhydrazines and 2-(1,2,3- Triazol-4-yl)-1,3,4-oxadiazoles, Letters in Organic Chemistry 2017; 14 (8) . https://dx.doi.org/10.2174/1570178614666170524130223

DOI https://dx.doi.org/10.2174/1570178614666170524130223	Print ISSN 1570-1786
Publisher Name Bentham Science Publisher	Online ISSN 1875-6255