Abstract
Over the last years, magnetic nanoparticles have received a great attention in cancer therapy and diagnosis. Magnetic drug targeting, is a particularly promising application in this area as the nanoparticles can be directed to the tumor by external magnetic field and concentrated the drug in this tumor tissue. In addition to this magnetic targeting, their inherent magnetic properties provide sensitive contrast enhancement in magnetic resonance imaging (MRI) and can, therefore, be visualized and used for theranostic purposes. Another important pillar of cancer therapy in which magnetic nanoparticles can be successfully employed is the hyperthermia induced either magnetically or by infrared irradiation. In addition, recent works have suggested that magnetic nanoparticles can be used for mechanical stimulation of cells affecting their viability. Most of these applications require modification of the physiochemical and surface properties of the magnetic nanoparticles to control their biodistribution, toxicity and pharmacokinetics. In relation to this, polymer coatings are probably the preference alternative to cover the magnetic nanoparticles for cancer treatment applications. In this review, we attempt to provide an overview of the recent advances in the development and applications of polymeric magnetic nanoparticles in cancer treatment and diagnosis including MRI, drug delivery, magnetic hyperthermia, photothermia and magnetolysis
Keywords: Magnetic nanoparticles, polymer coating, magnetic resonance imaging, drug delivery, hyperthermia, photothermia, magnetolysis.
Current Pharmaceutical Design
Title:Hybrid Polymeric-Magnetic Nanoparticles in Cancer Treatments
Volume: 23 Issue: 35
Author(s): Alexandra Munoz Bonilla and Pilar Herrasti Gonzalez *
Affiliation:
- Departamento de Quimica Fisica Aplicada, Facultad de Ciencias, Universidad Autonoma de Madrid, C/ Francisco Tomas y Valiente 7, 28049 Madrid,Spain
Keywords: Magnetic nanoparticles, polymer coating, magnetic resonance imaging, drug delivery, hyperthermia, photothermia, magnetolysis.
Abstract: Over the last years, magnetic nanoparticles have received a great attention in cancer therapy and diagnosis. Magnetic drug targeting, is a particularly promising application in this area as the nanoparticles can be directed to the tumor by external magnetic field and concentrated the drug in this tumor tissue. In addition to this magnetic targeting, their inherent magnetic properties provide sensitive contrast enhancement in magnetic resonance imaging (MRI) and can, therefore, be visualized and used for theranostic purposes. Another important pillar of cancer therapy in which magnetic nanoparticles can be successfully employed is the hyperthermia induced either magnetically or by infrared irradiation. In addition, recent works have suggested that magnetic nanoparticles can be used for mechanical stimulation of cells affecting their viability. Most of these applications require modification of the physiochemical and surface properties of the magnetic nanoparticles to control their biodistribution, toxicity and pharmacokinetics. In relation to this, polymer coatings are probably the preference alternative to cover the magnetic nanoparticles for cancer treatment applications. In this review, we attempt to provide an overview of the recent advances in the development and applications of polymeric magnetic nanoparticles in cancer treatment and diagnosis including MRI, drug delivery, magnetic hyperthermia, photothermia and magnetolysis
Export Options
About this article
Cite this article as:
Bonilla Munoz Alexandra and Gonzalez Herrasti Pilar *, Hybrid Polymeric-Magnetic Nanoparticles in Cancer Treatments, Current Pharmaceutical Design 2017; 23 (35) . https://dx.doi.org/10.2174/1381612823666170519115601
DOI https://dx.doi.org/10.2174/1381612823666170519115601 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Biological Relevance of Lysophospholipids and Green Solutions for Their Synthesis
Current Organic Chemistry Cisplatin-resistant MDA-MB-231 Cell-derived Exosomes Increase the Resistance of Recipient Cells in an Exosomal miR-423-5p-dependent Manner
Current Drug Metabolism Oncolytic Virus: Regulatory Aspects from Quality Control to Clinical Studies
Current Cancer Drug Targets Amaranth: A Pseudo-Cereal with Nutraceutical Properties
Current Nutrition & Food Science Emerging Role of the Ubiquitin-proteasome System as Drug Targets
Current Pharmaceutical Design Recent Patents on Influenza Vaccines
Recent Patents on Biotechnology Selection of Single Chain Antibody Fragments for Targeting Prostate Specific Membrane Antigen: A Comparison Between Cell-based and Antigen-based Approach
Protein & Peptide Letters Stem Cell Pharmacogenomics
Current Topics in Medicinal Chemistry Lectin-Carbohydrate Interactions: Implications for the Development of New Anticancer Agents
Current Medicinal Chemistry Anti-Apoptotic Genes in the Survival of Monocytic Cells During Infection
Current Genomics Clinical Trials of Targeted Alpha Therapy for Cancer
Reviews on Recent Clinical Trials Potential Therapeutic Approaches for the Treatment of Acute Myeloid Leukemia with AML1-ETO Translocation
Current Cancer Drug Targets Inhibitory Smad7: Emerging Roles in Health and Disease
Current Molecular Pharmacology Regulation of UDP Glucuronosyltransferase Genes
Current Drug Metabolism Amino Acid Transporter-Targeted Radiotracers for Molecular Imaging in Oncology
Current Medicinal Chemistry PET Imaging of MRP1 Function in the Living Brain: Method Development and Future Perspectives
Current Topics in Medicinal Chemistry Mechanisms of the Penetration of Blood-Borne Substances into the Brain
Current Neuropharmacology Thiopurine Immunomodulators in Ulcerative Colitis: Moving Forward with Current Evidence
Current Drug Targets Status of Anti-Lung Cancer Drug Patents Applications in China from 2003 to 2012
Recent Patents on Anti-Cancer Drug Discovery Patent Ductus Arteriosus in the Preterm Infant: An Update on Morbidity and Mortality
Current Pediatric Reviews