Abstract
Over the last years, magnetic nanoparticles have received a great attention in cancer therapy and diagnosis. Magnetic drug targeting, is a particularly promising application in this area as the nanoparticles can be directed to the tumor by external magnetic field and concentrated the drug in this tumor tissue. In addition to this magnetic targeting, their inherent magnetic properties provide sensitive contrast enhancement in magnetic resonance imaging (MRI) and can, therefore, be visualized and used for theranostic purposes. Another important pillar of cancer therapy in which magnetic nanoparticles can be successfully employed is the hyperthermia induced either magnetically or by infrared irradiation. In addition, recent works have suggested that magnetic nanoparticles can be used for mechanical stimulation of cells affecting their viability. Most of these applications require modification of the physiochemical and surface properties of the magnetic nanoparticles to control their biodistribution, toxicity and pharmacokinetics. In relation to this, polymer coatings are probably the preference alternative to cover the magnetic nanoparticles for cancer treatment applications. In this review, we attempt to provide an overview of the recent advances in the development and applications of polymeric magnetic nanoparticles in cancer treatment and diagnosis including MRI, drug delivery, magnetic hyperthermia, photothermia and magnetolysis
Keywords: Magnetic nanoparticles, polymer coating, magnetic resonance imaging, drug delivery, hyperthermia, photothermia, magnetolysis.
Current Pharmaceutical Design
Title:Hybrid Polymeric-Magnetic Nanoparticles in Cancer Treatments
Volume: 23 Issue: 35
Author(s): Alexandra Munoz Bonilla and Pilar Herrasti Gonzalez *
Affiliation:
- Departamento de Quimica Fisica Aplicada, Facultad de Ciencias, Universidad Autonoma de Madrid, C/ Francisco Tomas y Valiente 7, 28049 Madrid,Spain
Keywords: Magnetic nanoparticles, polymer coating, magnetic resonance imaging, drug delivery, hyperthermia, photothermia, magnetolysis.
Abstract: Over the last years, magnetic nanoparticles have received a great attention in cancer therapy and diagnosis. Magnetic drug targeting, is a particularly promising application in this area as the nanoparticles can be directed to the tumor by external magnetic field and concentrated the drug in this tumor tissue. In addition to this magnetic targeting, their inherent magnetic properties provide sensitive contrast enhancement in magnetic resonance imaging (MRI) and can, therefore, be visualized and used for theranostic purposes. Another important pillar of cancer therapy in which magnetic nanoparticles can be successfully employed is the hyperthermia induced either magnetically or by infrared irradiation. In addition, recent works have suggested that magnetic nanoparticles can be used for mechanical stimulation of cells affecting their viability. Most of these applications require modification of the physiochemical and surface properties of the magnetic nanoparticles to control their biodistribution, toxicity and pharmacokinetics. In relation to this, polymer coatings are probably the preference alternative to cover the magnetic nanoparticles for cancer treatment applications. In this review, we attempt to provide an overview of the recent advances in the development and applications of polymeric magnetic nanoparticles in cancer treatment and diagnosis including MRI, drug delivery, magnetic hyperthermia, photothermia and magnetolysis
Export Options
About this article
Cite this article as:
Bonilla Munoz Alexandra and Gonzalez Herrasti Pilar *, Hybrid Polymeric-Magnetic Nanoparticles in Cancer Treatments, Current Pharmaceutical Design 2017; 23 (35) . https://dx.doi.org/10.2174/1381612823666170519115601
DOI https://dx.doi.org/10.2174/1381612823666170519115601 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Red Blood Cells as Modulators of T Cell Growth and Survival
Current Pharmaceutical Design Inhibition of 17β -Hydroxysteroid Dehydrogenase (17β -HSD) by Imidazole-Based Compounds
Letters in Drug Design & Discovery Angiogenesis as a Therapeutic Target in Arthritis: Lessons from Oncology
Current Pharmaceutical Design Estrogens and Progression of Diabetic Kidney Damage
Current Diabetes Reviews Dexrazoxane for the Prevention of Cardiac Toxicity and Treatment of Extravasation Injury from the Anthracycline Antibiotics
Current Pharmaceutical Biotechnology Arene ruthenium(II) Complexes: The Promising Chemotherapeutic Agent in Inhibiting the Proliferation, Migration and Invasion
Mini-Reviews in Medicinal Chemistry Validated RP-HPLC Method for the Simultaneous Analysis of Gemcitabine and LY-364947 in Liposomal Formulations
Current Drug Targets In Vivo Optical Imaging in Gene & Cell Therapy
Current Gene Therapy Development of Functional Dark Chocolate by Incorporating Flaxseed (Linum usitatissimum) Oil and Honey with Improved Organoleptic and Textural Attributes
Current Nutrition & Food Science Cell-free Nucleic Acids as a Non-Invasive Route for Investigating Atherosclerosis
Current Pharmaceutical Design Protein Transduction Domains: Applications for Molecular Medicine
Current Gene Therapy miR-135a Suppresses Calcification in Senescent VSMCs by Regulating KLF4/STAT3 Pathway
Current Vascular Pharmacology A Focus on Microfluidics and Nanotechnology Approaches for the Ultra Sensitive Detection of MicroRNA
MicroRNA Gap Junctions as Targets for Cancer Chemoprevention and Chemotherapy
Current Drug Targets Anti-Cancer Therapy: Targeting the Mevalonate Pathway
Current Cancer Drug Targets The Role of Zinc in the Treatment of Taste Disorders
Recent Patents on Food, Nutrition & Agriculture Genetic and Pharmacological Modulation of Dendritic Cell-T Cell Interactions as a Therapeutic Strategy for Systemic Lupus Erythematosus
Current Gene Therapy Apis mellifera Proteomics: Where Will the Future Bee?
Current Proteomics Antineoplastic and Antimicrobial Potential of Novel Phytofabricated Silver Nanoparticles from <i>Pterospermum acerifolium</i> Leaf Extract
Nanoscience & Nanotechnology-Asia mTOR Inhibitors in Tuberous Sclerosis Complex
Current Neuropharmacology