The Effect of a Common Antibiotics Doxycycline on Non-Healing Chronic Wound

Title:The Effect of a Common Antibiotics Doxycycline on Non-Healing Chronic Wound

Volume: 18 Issue: 5

Author(s): Dixon H. Xu, Ziwen Zhu and Yujiang Fang*

Affiliation:

• Department of Microbiology, Immunology & Pathology, Des Moines University, Des Moines, Iowa, 50312,United States

Keywords: Doxycycline, chronic wound, diabetes, pathogenesis, MMPs, diabetic foot ulcers.

Abstract: Background: Up to 25% of diabetic patients will develop a diabetic foot ulcer. Chronic wounds such as diabetic foot ulcers often fail to heal with conventional therapies. In recent years, it has been identified that chronic wounds are usually associated with elevated level of matrix metalloproteinases (MMPs). Doxycycline, a cheap tetracycline antibiotic, has been shown to inhibit MMPs both in vitro and in vivo independent of its antimicrobial property.

Methods: We undertook a search through PUBMED for peer-reviewed research literature with doxycycline, chronic wound, diabetes, MMPs as key words.

Results: Seventy papers were included in the review. This review identified doxycycline is a very promising drug to be used in patients with diabetic foot ulcers because higher efficacy even in a very low dosage, little side effects in a lower dosage, inhibition of MMP as well as prevention/treatment of infection in the ulcers, beneficial to cardiovascular complications and cheap to manufacture.

Conclusion: In this review, we provide an overview of the roles of MMPs in the pathogenesis of chronic wounds and explore the potential application of doxycycline as a treatment option in managing chronic wounds such as diabetic foot ulcers.

Cite this article as:

Xu H. Dixon, Zhu Ziwen and Fang Yujiang*, The Effect of a Common Antibiotics Doxycycline on Non-Healing Chronic Wound, Current Pharmaceutical Biotechnology 2017; 18 (5) . https://dx.doi.org/10.2174/1389201018666170519095339

DOI https://dx.doi.org/10.2174/1389201018666170519095339	Print ISSN 1389-2010
Publisher Name Bentham Science Publisher	Online ISSN 1873-4316