Abstract
With the aim of offering patients a more effective drug therapy and with few side effects, it was believed in the perfect and unique interaction of the bioactive compound and the receptor or target macromolecule. This concept has changed, and multifunctional compounds show greater efficiency, particularly in the therapy of complex diseases, with a sum of origin. Among these ills, we quote: neurodegenerative diseases, cancer, parasitic and inflammatory. To fight these diseases, studies with multitarget flavonoids have been reported. Flavonoid compounds are natural products traditionally used as chemotherapy because of their numerous therapeutic activities. Here, we gather studies with multitarget in drug discovery flavonoids.
Keywords: Flavonoids, multi-target, drug, neurodegenerative, cancer, parasite, inflammation.
Mini-Reviews in Organic Chemistry
Title:Flavonoids as Multi-Target Compounds in Drug Discovery
Volume: 14 Issue: 4
Author(s): L. Scotti*, H. Ishiki, F.J.B. Mendonça Júnior, R.M.D. Cruz, J.F. Tavares, M.F.F.M. Diniz, J.M. Barbosa Filho and M.T. Scotti
Affiliation:
- Health Sciences Center, Federal University of Paraíba, Campus I, 58051-970, João Pessoa-PB,Brazil
Keywords: Flavonoids, multi-target, drug, neurodegenerative, cancer, parasite, inflammation.
Abstract: With the aim of offering patients a more effective drug therapy and with few side effects, it was believed in the perfect and unique interaction of the bioactive compound and the receptor or target macromolecule. This concept has changed, and multifunctional compounds show greater efficiency, particularly in the therapy of complex diseases, with a sum of origin. Among these ills, we quote: neurodegenerative diseases, cancer, parasitic and inflammatory. To fight these diseases, studies with multitarget flavonoids have been reported. Flavonoid compounds are natural products traditionally used as chemotherapy because of their numerous therapeutic activities. Here, we gather studies with multitarget in drug discovery flavonoids.
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Cite this article as:
Scotti L. *, Ishiki H. , Júnior Mendonça F.J.B. , Cruz R.M.D. , Tavares J.F. , Diniz M.F.F.M. , Filho Barbosa J.M. and Scotti M.T. , Flavonoids as Multi-Target Compounds in Drug Discovery, Mini-Reviews in Organic Chemistry 2017; 14 (4) . https://dx.doi.org/10.2174/1570193X14666170518112248
DOI https://dx.doi.org/10.2174/1570193X14666170518112248 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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