Simple and Rapid Determination of Paracetamol in Oral Pharmaceutical Preparations by a Home-use Glucometer for Paediatric Subministration

Title:Simple and Rapid Determination of Paracetamol in Oral Pharmaceutical Preparations by a Home-use Glucometer for Paediatric Subministration

Volume: 14 Issue: 4

Author(s): Ge Wang, Jing Zhu, Wei Wu*Wei Zhang*

Affiliation:

• Department of Pharmacy, Guilin Medical University, No. 109 Huancheng Road, Guilin 541004,China

• Department of Pharmacy, Guilin Medical University, No. 109 Huancheng Road, Guilin 541004,China

Keywords: Paracetamol, Glucometer, Paediatric subministration, Oral solid dosage form, Amperometric determination, Electrochemical sensor.

Abstract: Objective: A simple and rapid method for the measurement of paracetamol in oral pharmaceutical preparations by a commercial glucometer was proposed.

Methods: The established method was successfully applied to the determination of paracetamol in oral solid preparations, and exhibited the excellent capability of resisting interference from co-existing excipients. The commercial disposable test strips of hand-held glucometer showed high consistency of electrocatalytic activity toward the oxidation of paracetamol between each other.

Results: The linear range was from 0.2 mg/ml to 3.5 mg/ml with the detection limit of less than 0.2 mg/ml. The results demonstrated that the test strips can be used as a sensitive, selective and low-cost sensor for amperometric determination of paracetamol in oral solid dosage forms.

Conclusion: The unique application of household glucometer presented a convenient home-use tool for the paediatric subministration of the home medicine in common use.

Cite this article as:

Wang Ge , Zhu Jing , Wu Wei *, Zhang Wei *, Simple and Rapid Determination of Paracetamol in Oral Pharmaceutical Preparations by a Home-use Glucometer for Paediatric Subministration, Current Pharmaceutical Analysis 2018; 14 (4) . https://dx.doi.org/10.2174/1573412913666170509155135