Abstract
Background: Worldwide, Type 2 diabetes has become a growing health problem. While many research articles in the field of ethnopharmacology have focused on the antidiabetic properties of medicinal plant species, insufficient evidence remains regarding their therapeutic use. Studies using both in vitro and in vivo models are necessary to evaluate various medicinal plants species, used in folk medicine, by using scientific criteria.
Methods: This review focuses on isolated compounds from medicinal plant species that have reported antidiabetic activity in diabetes models. Searches using MEDLINE/PUBMED and SCOPUS databases were conducted to find articles in English on compounds isolated from plant species that have been tested using in vivo and/or in vitro diabetes models and published between 01/01/2005 and 12/31/2015.
Results: The majority of studies involved in vitro assays that used the analysis of enzymes and receptors to investigate the antidiabetic mechanisms of active compounds at the molecular level. Compounds that have been reported to have important anti-diabetic activity with defined mechanisms were identified, including quercetin, oleanolic acid, kaempferol, ursolic acid, rutin, β-sitosterol, and mangiferin.
Conclusion: This review contributes to the field of ethnopharmacology and should impact the design of new strategies in the search of novel compounds for the treatment of diabetic conditions.
Keywords: Antidiabetic activity, isolated compounds, in vivo and in vitro studies, plants, systematic review, natural products.
Current Diabetes Reviews
Title:Isolated Compounds from Natural Products with Potential Antidiabetic Activity - A Systematic Review
Volume: 14 Issue: 1
Author(s): Antonio C.M. Munhoz and Tania S. Frode*
Affiliation:
- Graduate Pharmacy Program, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, SC,Brazil
Keywords: Antidiabetic activity, isolated compounds, in vivo and in vitro studies, plants, systematic review, natural products.
Abstract: Background: Worldwide, Type 2 diabetes has become a growing health problem. While many research articles in the field of ethnopharmacology have focused on the antidiabetic properties of medicinal plant species, insufficient evidence remains regarding their therapeutic use. Studies using both in vitro and in vivo models are necessary to evaluate various medicinal plants species, used in folk medicine, by using scientific criteria.
Methods: This review focuses on isolated compounds from medicinal plant species that have reported antidiabetic activity in diabetes models. Searches using MEDLINE/PUBMED and SCOPUS databases were conducted to find articles in English on compounds isolated from plant species that have been tested using in vivo and/or in vitro diabetes models and published between 01/01/2005 and 12/31/2015.
Results: The majority of studies involved in vitro assays that used the analysis of enzymes and receptors to investigate the antidiabetic mechanisms of active compounds at the molecular level. Compounds that have been reported to have important anti-diabetic activity with defined mechanisms were identified, including quercetin, oleanolic acid, kaempferol, ursolic acid, rutin, β-sitosterol, and mangiferin.
Conclusion: This review contributes to the field of ethnopharmacology and should impact the design of new strategies in the search of novel compounds for the treatment of diabetic conditions.
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Cite this article as:
Munhoz C.M. Antonio and Frode S. Tania *, Isolated Compounds from Natural Products with Potential Antidiabetic Activity - A Systematic Review, Current Diabetes Reviews 2018; 14 (1) . https://dx.doi.org/10.2174/1573399813666170505120621
DOI https://dx.doi.org/10.2174/1573399813666170505120621 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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