Abstract
Background: Vitamin D deficiency is one determinant of secondary hyperparathyroidism in the course of Chronic Kidney Disease (CKD). However, numerous studies support the notion that vitamin D may exert pleiotropic effects aside of mineral metabolism control. Indeed, vitamin D receptor has been identified in a great variety of tissues and its activation contributes to the parathyroid, intestine, cardiovascular and immune system regulation.
Conclusion: We herein review vitamin D metabolism and effects with a specific emphasis on the potential impact of vitamin D receptor modulation aside from parathyroid hormone control.Keywords: CKD-MBD, vitamin D, paracalcitol, Vitamin D receptor, vitamin D deficiency.
Current Drug Metabolism
Title:Vitamin D Metabolism and Potential Effects of Vitamin D Receptor Modulation in Chronic Kidney Disease
Volume: 18 Issue: 7
Author(s): Antonio Bellasi*, Andrea Galassi, Michela Mangano, Luca Di Lullo and Mario Cozzolino
Affiliation:
- Renal and Dialysis Division Ospedale Sant’Anna-Como, ASST-Lariana, Via Ravona, 20 – 22020 Como,Italy
Keywords: CKD-MBD, vitamin D, paracalcitol, Vitamin D receptor, vitamin D deficiency.
Abstract: Background: Vitamin D deficiency is one determinant of secondary hyperparathyroidism in the course of Chronic Kidney Disease (CKD). However, numerous studies support the notion that vitamin D may exert pleiotropic effects aside of mineral metabolism control. Indeed, vitamin D receptor has been identified in a great variety of tissues and its activation contributes to the parathyroid, intestine, cardiovascular and immune system regulation.
Conclusion: We herein review vitamin D metabolism and effects with a specific emphasis on the potential impact of vitamin D receptor modulation aside from parathyroid hormone control.Export Options
About this article
Cite this article as:
Bellasi Antonio *, Galassi Andrea, Mangano Michela , Di Lullo Luca and Cozzolino Mario , Vitamin D Metabolism and Potential Effects of Vitamin D Receptor Modulation in Chronic Kidney Disease, Current Drug Metabolism 2017; 18 (7) . https://dx.doi.org/10.2174/1389200218666170427112735
DOI https://dx.doi.org/10.2174/1389200218666170427112735 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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