Abstract
Background: It is known that an increased oxidative stress is present in a wide range of diseases and, given the vulnerability of the central nervous system, its involvement has been in particular investigated in neurological and psychiatric diseases, including anxiety disorders.
Objective: In this review, we analyse the studies that have been conducted on the effects of oxidative stress modulators in anxiety, focusing on their possible clinical use.
Discussion and Conclusion: While preclinical studies have shown a clear anxiolytic-like effect of different oxidative stress modulators, less significant results have been obtained from clinical studies. After having reviewed the possible reasons for the discrepancy between preclinical and clinical data, we encourage further studies aimed at better investigating the utility of the modulation of oxidative stress in humans, as an adjunctive therapy of the traditional integrated psychotherapeutic and pharmacological approach.
Keywords: Oxidative stress modulators, anxiety disorders, anxiety models, reactive oxygen species, reactive nitrogen species, lipid peroxidation.
Current Drug Targets
Title:Potential Use of Modulators of Oxidative Stress as Add-on Therapy in Patients with Anxiety Disorders
Volume: 19 Issue: 6
Author(s): Paolo Boldrini*, Antonella Fusco, Ferdinando Nicoletti, Aldo Badiani and Luciano Saso
Affiliation:
- Department of Physiology and Pharmacology ,Italy
Keywords: Oxidative stress modulators, anxiety disorders, anxiety models, reactive oxygen species, reactive nitrogen species, lipid peroxidation.
Abstract: Background: It is known that an increased oxidative stress is present in a wide range of diseases and, given the vulnerability of the central nervous system, its involvement has been in particular investigated in neurological and psychiatric diseases, including anxiety disorders.
Objective: In this review, we analyse the studies that have been conducted on the effects of oxidative stress modulators in anxiety, focusing on their possible clinical use.
Discussion and Conclusion: While preclinical studies have shown a clear anxiolytic-like effect of different oxidative stress modulators, less significant results have been obtained from clinical studies. After having reviewed the possible reasons for the discrepancy between preclinical and clinical data, we encourage further studies aimed at better investigating the utility of the modulation of oxidative stress in humans, as an adjunctive therapy of the traditional integrated psychotherapeutic and pharmacological approach.
Export Options
About this article
Cite this article as:
Boldrini Paolo *, Fusco Antonella , Nicoletti Ferdinando , Badiani Aldo and Saso Luciano, Potential Use of Modulators of Oxidative Stress as Add-on Therapy in Patients with Anxiety Disorders, Current Drug Targets 2018; 19 (6) . https://dx.doi.org/10.2174/1389450118666170425153356
DOI https://dx.doi.org/10.2174/1389450118666170425153356 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Non-Analgesic Effects of Opioids: Neuroprotection in the Retina
Current Pharmaceutical Design Adolescent Alcohol Abuse and Dependence: Development, Diagnosis, Treatment and Outcomes
Current Psychiatry Reviews Coenzyme Q10 Reduction with Statins: Another Pleiotropic Effect
Current Drug Therapy Preface
Current Physical Chemistry Stem Cell Regenerative Potential Combined with Nanotechnology and Tissue Engineering for Myocardial Regeneration
Current Stem Cell Research & Therapy Microwave-assisted Olefin Metathesis as Pivotal Step in the Synthesis of Bioactive Compounds
Current Medicinal Chemistry Role of Endogenous GLP-1 and its Agonists in Osteopenia and Osteoporosis: But We Little Know Until Tried
Current Diabetes Reviews Myocardial Infarction with and without ST-segment Elevation: a Contemporary Reappraisal of Similarities and Differences
Current Cardiology Reviews Novel Molecular Targets for the Prevention of Fetal Alcohol Syndrome
Recent Patents on CNS Drug Discovery (Discontinued) Non Peptidic Ligands at the Opioid Receptor Like-1 (ORL-1)
Mini-Reviews in Medicinal Chemistry Protein-Protein Interactions in Membranes
Protein & Peptide Letters Psychological Interventions for Neuropsychiatric Disturbances in Mild and Moderate Alzheimer’s Disease: Current Evidences and Future Directions
Current Alzheimer Research Commentary: Participation of Sox-1 Expression and Signaling of β-Catenin in the Pathophysiology of Generalized Seizures in Cerebellum of Rat
CNS & Neurological Disorders - Drug Targets Influence of Transition Metal Ion Doping on the Crystallization and Photocatalytic Activity of TiO<sub>2</sub> Prepared Via Adsorption Phase Synthesis
Current Nanoscience Communication of Suicidality via Social Media
Adolescent Psychiatry Green Tea (Camellia sinensis) Protects Against Arsenic Neurotoxicity via Antioxidative Mechanism and Activation of Superoxide Dismutase Activity
Central Nervous System Agents in Medicinal Chemistry HIV Testing in Women in Relation to Intimate Partner Violence and Substance Use: A Systematic Review
Current Women`s Health Reviews Patented Biomarkers of Peripheral Blood for the Early Detection of Cancer
Recent Patents on Biomarkers Molecular Linkages Between Diabetes and Alzheimer's Disease: Current Scenario and Future Prospects
CNS & Neurological Disorders - Drug Targets Editorial [Hot Topic: Molecular Pharmacology of the GABAA Receptor (Guest Editor: Gustav Akk)]
Current Neuropharmacology