Abstract
Flavonoids are naturally occurring phenolic compounds named as 2-phenyl-1-benzopyran- 4-one and classified into several subclasses according to their basic chemical structures such as flavones, flavonols, flavanones, flavanonols, and flavanols. Among them, flavonols (3-hydroxyflavone), containing a 3-hydroxyl group in association with its 4-keto group and double bond between 2- and 3- carbon atoms, have the best electron conjugated skeleton in flavonoid family, providing several resonance structures and chelating ability, through which various pharmacological activities such as antiviral, antitumour, anti-inflammatory, anticholinesterase, cytotoxicity and particularly high antioxidant activity are demonstrated. They prevent generation of free radicals and are used as food preservatives. Their strong electron conjugation provides them with fluorescent property, which make them used as imaging agents for therapeutic purpose.
Keywords: Flavonoids, flavonols, 3-hydroxyflavones, pharmacological activities, fluorescent, dye.
Mini-Reviews in Medicinal Chemistry
Title:Recent Advances on 3-Hydroxyflavone Derivatives: Structures and Properties
Volume: 18 Issue: 2
Author(s): Burcu Butun, Gulacti Topcu and Turan Ozturk*
Affiliation:
- Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Istanbul,Turkey
Keywords: Flavonoids, flavonols, 3-hydroxyflavones, pharmacological activities, fluorescent, dye.
Abstract: Flavonoids are naturally occurring phenolic compounds named as 2-phenyl-1-benzopyran- 4-one and classified into several subclasses according to their basic chemical structures such as flavones, flavonols, flavanones, flavanonols, and flavanols. Among them, flavonols (3-hydroxyflavone), containing a 3-hydroxyl group in association with its 4-keto group and double bond between 2- and 3- carbon atoms, have the best electron conjugated skeleton in flavonoid family, providing several resonance structures and chelating ability, through which various pharmacological activities such as antiviral, antitumour, anti-inflammatory, anticholinesterase, cytotoxicity and particularly high antioxidant activity are demonstrated. They prevent generation of free radicals and are used as food preservatives. Their strong electron conjugation provides them with fluorescent property, which make them used as imaging agents for therapeutic purpose.
Export Options
About this article
Cite this article as:
Butun Burcu , Topcu Gulacti and Ozturk Turan*, Recent Advances on 3-Hydroxyflavone Derivatives: Structures and Properties, Mini-Reviews in Medicinal Chemistry 2018; 18 (2) . https://dx.doi.org/10.2174/1389557517666170425102827
DOI https://dx.doi.org/10.2174/1389557517666170425102827 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Heart in Sepsis: From Basic Mechanisms to Clinical Management
Current Vascular Pharmacology From Adipose Tissue Protein Secretion to Adipopharmacology of Disease
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Paliperidone Use in the Elderly
Current Drug Safety Specific Nutritional Needs for Children. Are Children Small Adults?
Current Nutrition & Food Science Low-Density Lipoprotein Cholesterol (LDL-C): How Low?
Current Vascular Pharmacology Novel Glycomimetics: Anomeric and N-Glycosyl Sulfonamides
Current Organic Chemistry Mass Spectrometry in Doping Control Analysis
Current Organic Chemistry Experimental Approaches Towards Allergic Asthma Therapy-Murine Asthma Models
Recent Patents on Inflammation & Allergy Drug Discovery Epigenetic Modifications of the Nuclear Factor Kappa B Signalling Pathway and its Impact on Inflammatory Bowel Disease
Current Pharmaceutical Design Neck Circumference and its Correlation to Other Anthropometric Parameters and Finnish Diabetes Risk Score (FINDRISC)
Current Diabetes Reviews PTP1b Inhibition, A Promising Approach for the Treatment of Diabetes Type II
Current Topics in Medicinal Chemistry Mitochondria: “Mood Altering Organelles” that Impact Disease Throughout the Nervous System
Current Neurovascular Research Aqueous Extract of <i>Cola nitida</i> and <i>Garcinia kola</i> Synergistically Enhances Hippocampal-hypothalamic Glutamate and Na+ /K+ -ATPase Activity in Male Wistar Rats
Current Drug Discovery Technologies Computer Aided Drug Design Strategies Used in the Discovery of Fructose 1, 6-Bisphosphatase Inhibitors
Current Pharmaceutical Design Use of Clinically Available PPAR Agonists for Heart Failure; Do the Risks Outweigh the Potential Benefits?
Current Molecular Pharmacology A Stress Repair Mechanism That Maintains Vertebrate Structure During Stress
Cardiovascular & Hematological Disorders-Drug Targets Current Biology of MTP: Implications for Selective Inhibition
Current Topics in Medicinal Chemistry Role of ARBs in the Blood Hypertension Therapy and Prevention of Cardiovascular Events
Current Drug Targets Implantable Continuous Glucose Sensors
Current Diabetes Reviews Common Variant in VEGFA and Response to Anti-VEGF Therapy for Neovascular Age-Related Macular Degeneration
Current Molecular Medicine