Abstract
Background & Objective: Medical cannabis is increasingly used as a treatment or adjunct treatment with different levels of efficacy in several neurological disorders or related symptoms (such as multiple sclerosis, autism, Parkinson and Alzheimer disease, Tourette’s syndrome, Huntington’s disease, neuropathic pain, epilepsy, headache), as well as in other medical conditions (e.g. nausea and vomiting, glaucoma, appetite stimulation, cancer, inflammatory conditions, asthma). Nevertheless, a number of neurological adverse effects from use of medical cannabis on the short- and on the longterm have been reported, in addition to other adverse health events.
Conclusion: It has been noticed that the use of medical cannabis can lead to a paradoxical effects depending on the amount of delta-9-tetrahydrocannabinol (THC) -like cannabinoids the preparation contain. Accordingly, some neurological disorders or symptoms (e.g. multiple sclerosis, seizures, epilepsy, headache) may be caused or exacerbated by the same treatment supposed to cure them. The current review presents an update of the neurological adverse effects resulting from the use of cannabis for medical purposes, highlighting the need to weigh the benefits and risks, when using cannabinoidbased treatments.Keywords: Adverse effects, antipsychotic, compounds, medical cannabis, neurological disorders, Parkinson.
CNS & Neurological Disorders - Drug Targets
Title:Neurological Disorders in Medical Use of Cannabis: An Update
Volume: 16 Issue: 5
Author(s): Renata Solimini*, Maria Concetta Rotolo, Simona Pichini and Roberta Pacifici
Affiliation:
- National Centre on Addiction and Doping, Istituto Superiore di Sanità, viale Regina Elena 299, 00161, Roma,Italy
Keywords: Adverse effects, antipsychotic, compounds, medical cannabis, neurological disorders, Parkinson.
Abstract: Background & Objective: Medical cannabis is increasingly used as a treatment or adjunct treatment with different levels of efficacy in several neurological disorders or related symptoms (such as multiple sclerosis, autism, Parkinson and Alzheimer disease, Tourette’s syndrome, Huntington’s disease, neuropathic pain, epilepsy, headache), as well as in other medical conditions (e.g. nausea and vomiting, glaucoma, appetite stimulation, cancer, inflammatory conditions, asthma). Nevertheless, a number of neurological adverse effects from use of medical cannabis on the short- and on the longterm have been reported, in addition to other adverse health events.
Conclusion: It has been noticed that the use of medical cannabis can lead to a paradoxical effects depending on the amount of delta-9-tetrahydrocannabinol (THC) -like cannabinoids the preparation contain. Accordingly, some neurological disorders or symptoms (e.g. multiple sclerosis, seizures, epilepsy, headache) may be caused or exacerbated by the same treatment supposed to cure them. The current review presents an update of the neurological adverse effects resulting from the use of cannabis for medical purposes, highlighting the need to weigh the benefits and risks, when using cannabinoidbased treatments.Export Options
About this article
Cite this article as:
Solimini Renata *, Rotolo Concetta Maria , Pichini Simona and Pacifici Roberta, Neurological Disorders in Medical Use of Cannabis: An Update, CNS & Neurological Disorders - Drug Targets 2017; 16 (5) . https://dx.doi.org/10.2174/1871527316666170413105421
DOI https://dx.doi.org/10.2174/1871527316666170413105421 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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