Differential Pulse Voltammetric Determination of Piroxicam on Lanthanide Ferric Oxide Nanoparticles-Carbon Paste Modified Electrode

Title:Differential Pulse Voltammetric Determination of Piroxicam on Lanthanide Ferric Oxide Nanoparticles-Carbon Paste Modified Electrode

Volume: 14 Issue: 3

Author(s): Isaac Yves Lopes de Macedo, Morgana Fernandes Alecrim, Luane Ferreira Garcia, Aparecido Ribeiro de Souza, Wallans Torres Pio dos Santos, Eric de Souza Gil*, Laura M. Cubillana-Aguilera and Jose Maria Palacios-Santander*

Affiliation:

• Faculdade de Farmacia e Universidade Federal de Goias (UFG), Goiania – GO,Brazil

• Departamento de Quimica Analitica, Instituto Universitario de Investigacion en Microscopia Electronica y Materiales (IMEYMAT), Facultad de Ciencias, Universidad de Cadiz, Campus Universitario de Puerto Real, Poligono del Rio San Pedro S/N, 11510, Puerto Real, Cadiz,Spain

Keywords: LaFeO3, nanoparticles, modified carbon paste electrode, electroanalysis, voltammetry, piroxicam, oxidation.

Abstract: Introduction: Piroxicam (PRX) is a widely consumed anti-inflammatory drug, and the assays of its tablets and gels for quality control are mostly performed through High Performance Liquid Chromatography with Ultraviolet Detector (HPLC-UV).

Methods: In this regard, an alternate approach, LaFeO3 nanoparticles-modified carbon paste electrode was prepared in order to carry out PRX analysis by using voltammetric approaches.

Results: The modified electrode showed better analytical signal. The calibration curve is in the concentration range of 9.00 and 180.00 µmol·L-1 and the limit of detection was obtained as 1.00 µmol·L1 for PRX. The calculated recovery rate was fairly good (99.14%) in comparison with the declared value in the commercial product.

Conclusion: As shown by the low overall process cost, performance quickness and analytical results, the proposed method of electroanalysis with the LaFeO3 nanoparticles-modified carbon paste electrode presents a viable and interesting alternative approach to identification and determination of PRX compound in commercial products.

Cite this article as:

Lopes de Macedo Yves Isaac , Alecrim Fernandes Morgana , Garcia Ferreira Luane , Ribeiro de Souza Aparecido, Pio dos Santos Torres Wallans , de Souza Gil Eric *, Cubillana-Aguilera M. Laura and Palacios-Santander Maria Jose*, Differential Pulse Voltammetric Determination of Piroxicam on Lanthanide Ferric Oxide Nanoparticles-Carbon Paste Modified Electrode, Current Pharmaceutical Analysis 2018; 14 (3) . https://dx.doi.org/10.2174/1573412913666170410131223