Molecular Design and Medicinal Applications of Nano-Nitric Oxide Delivery Systems

Title:Molecular Design and Medicinal Applications of Nano-Nitric Oxide Delivery Systems

Volume: 25 Issue: 12

Author(s): Kim Truc Nguyen, Zhuoran Wu, Tiantian Huang and Chor Yong Tay*

Affiliation:

• School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798,Singapore

Keywords: Nitric oxide, nano-biomaterials, biomedical applications, molecular design, controlled delivery, therapeutic gas.

Abstract: Background: Nitric oxide (NO) plays important regulatory roles in a plethora of biological functions and thus holds tremendous potential to be exploited for clinical uses. However, the chemistries in the molecular design of nano-nitric oxide delivery systems is currently lacking.

Objective: The overarching aim of this review is to provide the readers with the fundamentals that relate to the design of NO release molecules (NORMs), loading and releasing mechanism, as well as delivery of NORMs for nanotherapeutics.

Methods: We conducted a thorough literature search on the design and synthesis of NORMs, as well as the current state-of-the-art NO compatible delivery platforms to address various clinical needs.

Results: N-diazeniumdiolate and S-nitrosothiol based NO molecules are among the most widely used NORMs for anti-cancer and anti-microbial applications. The innovative integration of these NORMs with cytocompatible organic and inorganic nanocarriers enabled controlled spatiotemporal delivery and release of NO at the targeted diseased sites.

Conclusion: We have provided a comprehensive summary of the fundamental chemistries underpinning the molecular design of the NORMs and critically assessed the recent advancements of nano-NO delivery systems for advanced biomedical applications.

Cite this article as:

Nguyen Truc Kim , Wu Zhuoran, Huang Tiantian and Tay Yong Chor *, Molecular Design and Medicinal Applications of Nano-Nitric Oxide Delivery Systems, Current Medicinal Chemistry 2018; 25 (12) . https://dx.doi.org/10.2174/0929867324666170407141222