The Frequency of HLA-B27 in a Colombian Population with Signs of Spondyloarthritis | BenthamScience

The Frequency of HLA-B27 in a Colombian Population with Signs of Spondyloarthritis

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Author(s): Consuelo Romero-Sánchez*, Lorena Chila M, Alberto Gómez, María Consuelo Casas, Wilson Bautista-Molano, Ignacio Briceño, Juan Camilo Rueda, Juliette De Avila, John Londoño, Rafael Valle-Oñate.

Journal Name: Current Rheumatology Reviews

Abstract:

Background: The strong association between HLA-B27 and spondyloarthritis (SpA) has demonstrated that typing the HLA-B27 antigen is a crucial step in diagnosis and aids in defining the progression and severity of disease.

Objective: To describe the frequency of HLA-B27 in Colombian individuals with clinical manifestations associated with SpA.

Materials and Methodology: We retrospectively analyzed 4109 HLA-B27 typing requests to the Hospital Militar Central and the Instituto de Referencia Andino from Colombian individuals with clinical signs suggestive of SpA between 2009 and 2012. We used basic digital cytometry followed by Polymerase Chain Reaction with sequence specific primers when confirmation was needed. We determined the frequency of HLA-B27 in the population and levels of association of HLA-B27 with SpA.

Results: Our population included 1585 men (36.8%) and 2524 women (61.4%). The predominant age range was between 19 and 45 years (49.9%). The majority (95.4%) of the study population came from the Andean region and eastern plains. Only a small fraction (12.1%) of the 497 subjects were HLA-B27 positive, among whom 56.9% were male, and 62.5% were between 19 and 45 years old (p <0.0001). Women constituted 43.1% of the sample, with 7.8% under 18 years old and 37.4% above 45 years old. The most frequent clinical manifestations were peripheral: synovitis, polyarthralgias, musculoskeletal pain and heel pain.

Conclusion: The frequency of the HLA-B27 allele in individuals with clinical signs suggestive of SpA was low, in accordance with the lower prevalence found in Colombian patients diagnosed with SpA compared to American and European population.

Keywords: flow cytometry, HLA-B27, Polymerase Chain Reaction, Ankylosing spondylitis, Autoimmune diseases

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1573397113666170329121552
Price: $95

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