Synthesis and Antimicrobial Activity of Some Novel Substituted 3-(Thiophen-2-yl)pyrazole-based Heterocycles

Title:Synthesis and Antimicrobial Activity of Some Novel Substituted 3-(Thiophen-2-yl)pyrazole-based Heterocycles

VOLUME: 14 ISSUE: 11

Author(s):Bakr F. Abdel-Wahab*, Abdelbasset A. Farahat, Ghada E. A. Awad and Gamal A. El-Hiti*

Affiliation:Department of Chemistry, College of Science and Humanities, Shaqra University, Duwadimi, Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Department of Chemistry of Natural and Microbial Products, National Research Center, Dokki, 12622 Giza, Department of Optometry, Cornea Research Chair, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433

Keywords:Drug design, antimicrobial activity, microorganisms, 3-(thiophen-2-yl)pyrazoles, hydrazides, inhibition zone.

Abstract:Background: A series of novel substituted 3-(thiophen-2-yl)pyrazoles was synthesized efficiently and in high yields using simple and convenient procedures starting from 1-phenyl-3- (thiophen-2-yl)-1H-pyrazole-4-carbaldehyde.

Methods: The structures of the newly synthesized products were established and their antimicrobial activities were investigated against some bacteria and fungi.

Results and Conclusion: The products showed excellent antimicrobial activities against the tested microorganism compared to the standard antibacterial and antifungal drugs.