Abstract
Background & Objective: Chagas disease or American trypanosomiasis is a major parasitic disease in Latin America with restricted available treatment: nifurtimox and benznidazole. These two drugs are ineffective in the chronic phase of the disease; therefore, there is a need for the development of new, efficient and safe drugs for the treatment of this pathology. With this goal, one of the promising targets is trypanothione reductase (TR), a key enzyme in the metabolism of Trypanosoma cruzi.
Conclusion: In this review, we analyse the importance of TR as a drug target, as well as the well-known and new inhibitors reported in the last decade as potential therapeutic agents for Chagas disease.
Keywords: Chagas disease, trypanothione reductase, Trypanosoma cruzi, target, drugs, inhibitors.
Mini-Reviews in Medicinal Chemistry
Title:Trypanothione Reductase: A Target for the Development of Anti- Trypanosoma cruzi Drugs
Volume: 17 Issue: 11
Author(s): Karina Vázquez, Margot Paulino, Cristian O. Salas, Juan J. Zarate-Ramos, Brenda Vera and Gildardo Rivera*
Affiliation:
- Centro de Biotecnologia Genomica, Instituto Politecnico Nacional, Boulevard del Maestro, s/n, Esquina Elías Piña, Reynosa, 88710,Mexico
Keywords: Chagas disease, trypanothione reductase, Trypanosoma cruzi, target, drugs, inhibitors.
Abstract: Background & Objective: Chagas disease or American trypanosomiasis is a major parasitic disease in Latin America with restricted available treatment: nifurtimox and benznidazole. These two drugs are ineffective in the chronic phase of the disease; therefore, there is a need for the development of new, efficient and safe drugs for the treatment of this pathology. With this goal, one of the promising targets is trypanothione reductase (TR), a key enzyme in the metabolism of Trypanosoma cruzi.
Conclusion: In this review, we analyse the importance of TR as a drug target, as well as the well-known and new inhibitors reported in the last decade as potential therapeutic agents for Chagas disease.
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Cite this article as:
Vázquez Karina , Paulino Margot , Salas O. Cristian , Zarate-Ramos J. Juan, Vera Brenda and Rivera Gildardo *, Trypanothione Reductase: A Target for the Development of Anti- Trypanosoma cruzi Drugs, Mini-Reviews in Medicinal Chemistry 2017; 17 (11) . https://dx.doi.org/10.2174/1389557517666170315145410
DOI https://dx.doi.org/10.2174/1389557517666170315145410 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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