A Rapid, Facile and Chromatography-Free Microwave Assisted Protocol for the Synthesis of Highly Functionalised Dihydrospiro[indeno[1,2-b] quinoline-10,3'-indole]-2',4',11-trione Derivatives

Title:A Rapid, Facile and Chromatography-Free Microwave Assisted Protocol for the Synthesis of Highly Functionalised Dihydrospiro[indeno[1,2-b] quinoline-10,3'-indole]-2',4',11-trione Derivatives

Volume: 4 Issue: 2

Author(s): Animesh Mondal and Chhanda Mukhopadhyay*

Affiliation:

• Department of Chemistry, Faculty of Calcutta University, 92 APC Road, Kolkata-700009,India

Keywords: Catalyst-free, chromatography-free procedure, environmental friendly, microwave-assisted, multicomponent protocols, one-pot synthesis, spirocyclic compounds, three-component reaction.

Abstract: Background: We describe herein a convenient one-pot, microwave-assisted methodology for the synthesis of dihydrospiro[indeno[1,2-b]quinoline-10,3'-indole]-2',4',11(1'H,5H,5'H)-trione derivatives from enaminones, isatins and indane-1,3-dione under catalyst-free condition.

Method: The advantages of this microwave-assisted protocol are simplicity, rapidity, high yielding and environmentally benign procedure.

Result: In addition, one of the most important aspects is that all the compounds were isolated in good to excellent yields without the need for any chromatographic separations.

Conclusion: Microwave-assisted synthesis has become a mainstream method in both academia and industry, because of the commercially availability of instruments which reduces dramatically the reaction times: from days and hours to minutes and seconds. Here, we have successfully developed an effective, rapid, clean and most importantly, environmentally benign three component one pot methodology using catalyst-free micro-wave irradiation.

Cite this article as:

Mondal Animesh and Mukhopadhyay Chhanda *, A Rapid, Facile and Chromatography-Free Microwave Assisted Protocol for the Synthesis of Highly Functionalised Dihydrospiro[indeno[1,2-b] quinoline-10,3'-indole]-2',4',11-trione Derivatives, Current Microwave Chemistry 2017; 4 (2) . https://dx.doi.org/10.2174/2213335604666170315114337

DOI https://dx.doi.org/10.2174/2213335604666170315114337	Print ISSN 2213-3356
Publisher Name Bentham Science Publisher	Online ISSN 2213-3364