Background: We describe herein a convenient one-pot, microwave-assisted methodology
for the synthesis of dihydrospiro[indeno[1,2-b]quinoline-10,3'-indole]-2',4',11(1'H,5H,5'H)-trione
derivatives from enaminones, isatins and indane-1,3-dione under catalyst-free condition.
Method: The advantages of this microwave-assisted protocol are simplicity, rapidity, high yielding
and environmentally benign procedure.
Result: In addition, one of the most important aspects is that all the compounds were isolated in good
to excellent yields without the need for any chromatographic separations.
Conclusion: Microwave-assisted synthesis has become a mainstream method in both academia and
industry, because of the commercially availability of instruments which reduces dramatically the
reaction times: from days and hours to minutes and seconds. Here, we have successfully developed an
effective, rapid, clean and most importantly, environmentally benign three component one pot
methodology using catalyst-free micro-wave irradiation.