Alcohol Induced Hepato Cardiotoxicity and Oxidative Damage in Rats: The Protective Effect of n-butanol Extract of Green Tea (Camellia sinensis (L.) Kuntze)

Title:Alcohol Induced Hepato Cardiotoxicity and Oxidative Damage in Rats: The Protective Effect of n-butanol Extract of Green Tea (Camellia sinensis (L.) Kuntze)

Volume: 17 Issue: 1

Author(s): Amel Amrani*, Nassima Boubekri, Somia Lassad, Djamila Zama, Fadil Benayache and Samir Benayache

Affiliation:

• Department of Animal Biology, Faculty of Natural and Life Sciences, University Constantine 1., Constantine,Algeria

Keywords: Alcohol, hepatotoxicity, cardiotoxicity, Camellia sinensis, oxidative stress, antioxidant.

Abstract: Background: The principal aim of this study was to investigate the oxidative effects of acute alcohol consumption on the functions of the heart and the liver and the possible modification of this effect by phenolic compounds from n-butanol extract of Camellia sinensis supplementation.

Method: Three experimental groups of rats were used: control, ethanol-exposed (40% v/v, 5 g/kg per oral every 12 hours for 3 doses, binge model), and ethanol-exposed plus n-butanol extract of Camellia sinensis (100 mg/kg once a day for three days before and simultaneously with ethanol administration). Serum transaminases, cholesterol, triglycerides, lipid peroxidation (MDA), reduced glutathione (GSH) and glutathione peroxidase (GPx) were estimated to assess organs damage.

Results: n-butanol extract of Camellia sinensis at a dose of 100 mg/kg body weight exhibited a significant reversal effect in all biochemical parameters measured such as extent of lipid peroxidation, GSH, lipid profile, and serum aminotransferase activities.

Conclusion: These results suggest that n-butanol extract of Camellia sinensis protected the heart and the liver from binge ethanol induced injury through attenuating oxidative stress.

Cite this article as:

Amrani Amel*, Boubekri Nassima, Lassad Somia, Zama Djamila, Benayache Fadil and Benayache Samir, Alcohol Induced Hepato Cardiotoxicity and Oxidative Damage in Rats: The Protective Effect of n-butanol Extract of Green Tea (Camellia sinensis (L.) Kuntze), Cardiovascular & Hematological Disorders-Drug Targets 2017; 17 (1) . https://dx.doi.org/10.2174/1871529X17666170310101727

DOI https://dx.doi.org/10.2174/1871529X17666170310101727	Print ISSN 1871-529X
Publisher Name Bentham Science Publisher	Online ISSN 2212-4063