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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Curcumin: Not So Spicy After All

Author(s): Amitabh Jha*, Prabhu. P. Mohapatra, Salma A. AlHarbi and Nusrat Jahan

Volume 17, Issue 15, 2017

Page: [1425 - 1434] Pages: 10

DOI: 10.2174/1389557517666170228114234

Price: $65

Abstract

Background: This is a short review on the most recent studies on curcumin and its analogs, including the studies from the laboratories of authors. The diverse medicinal properties of curcumin itself reported in the recent years are reviewed. Although curcumin has shown great potential in treating various diseases, it has not been approved as a clinical drug candidate because of its poor pharmacokinetics.

Method: The recent methods developed to solve this problem are briefly described.

Conclusion: The biological and other properties of synthetic curcumin analogs (diarylheptanoids and diarylpentanoid monocarbonyl derivatives) reported in the recent literature are also presented.

Keywords: Anticancer, antioxidant, curcumin analogs, curcumin, diarylheptanoids, diarylpentanoids, formulations, mechanism of action, Michael acceptor, pharmacokinetics, topoisomerase IIα inhibitors.

Graphical Abstract

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