Background: The design of environmentally benign protocols complying with the
‘Green Chemistry principles’ such as energy consumption, atom efficiency and sustainability has
evoked immense interest among researchers.
Methods: Multicomponent reactions provide powerful synthetic method for the rapid generation
of structurally diverse combinatorial libraries for drug discovery. These reactions avert the need
for isolation as well as purification of intermediates, resulting in maximization of yield and reduction
of waste, rendering the protocol environmentally benevolent. Meldrum’s acid has been used
in the design and synthesis of diverse types of heterocyclic compounds and considered as a vital
building block in organic synthesis.
Conclusion: This review describes the multicomponent reactions of Meldrum’s acid which serves
as a starting material for the synthesis of heterocycles like pyrazines, quinolines, chromenes, pyrans,
zwitter ions, pyridines, pyrimidines, pyrrolidiones, benzothiazines, benzoxazepines, amides,
esters, spiro compounds, acids etc. with array of pharmacological properties.