Introduction: Fluoroquinolones are most widely used for empirical treatment of
gastrointestinal disease due to emergence of drug resistant strains to other antimicrobials. They are also
indulged in cutaneous adverse drug reactions with varying form of severity.
Case Presentation: A 43 year old male patient developed fixed drug eruptions after administration of
tablet norfloxacin and metronidazole for the treatment of colicky abdominal pain with diarrhoea.
Erythematous rashes involved whole body including buccal mucosa. Causative drugs were stopped and
patient was managed by local as well as systemic therapy and was recovered after 20 days.
Conclusion: Awareness among healthcare professionals regarding FDEs and its management is
essential to prevent mortality and morbidity and counsel patient regarding future use of drugs causing
reactions with physician’s advice.
Keywords: Cross sensitivity, fixed drug eruptions, metronidazole, norfloxacin, empirical treatment, FDE.
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