Current Vascular Pharmacology

Dimitri P. Mikhailidis  
Academic Head, Deptartment of Clinical Biochemistry
Royal Free Hospital Campus
University College London Medical School
University College London (UCL)
Pond Street
London, NW3 2QG
UK

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Surrogates of Insulin Sensitivity and Indices of Cardiometabolic Profile in Obesity

Author(s): Djordje S. Popovic, Edita Stokic, Milena Mitrovic, Dragana Tomic-Naglic, Radoslav Pejin, Tijana Icin, Bojan Vukovic, Zeljko Zivanovic, Sladjana Pejakovic, Branka Kovacev-Zavisic.

Graphical Abstract:


Abstract:

Background and Objectives: Obesity is often associated with insulin resistance (IR). We considered different IR indexes: the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) index, the two specimen (0 and 120 min) oral glucose tolerance test Matsuda Index (MI) and the Homeostasis Model Assessment-Adiponectin (HOMA-AD) index. These IR indexes were compared with indicators of the cardiometabolic profile.

Method: This cross-sectional study enrolled 60 obese individuals without previous history of diabetes. Anthropometrical, ultrasound and laboratory examinations were conducted.

Results: All 3 indexes significantly correlated with indicators of central obesity, systolic and diastolic blood pressure, inflammation parameters, liver enzymes, HbA1c and some lipid parameters. The majority of correlation coefficients were the highest for HOMA-AD, but only the difference in correlation with waist circumference comparing with MI was statistically significant. HOMA-IR directly, and MI indirectly, significantly correlated with age, while HOMA-AD significantly directly correlated with the mean carotid artery intima media thickness (CAIMT). MI showed the best performances in predicting non-alcoholic fatty liver disease and pathologically increased CAIMT; HOMA-AD was the best in predicting metabolic syndrome, while HOMA-IR demonstrated the poorest performances in the prediction of all 3 conditions. There were no statistically significant differences in predicting performances of the analysed indexes.

Conclusion: The HOMA-AD and MI are not superior compared with the HOMA-IR, in the identification of obese individuals with a proatherogenic cardiometabolic profile.

Keywords: Adiponectin, adipose tissue, atherosclerosis, insulin resistance, insulin sensitivity, metabolic syndrome, nonalcoholic fatty liver disease, obesity.

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Article Details

VOLUME: 15
ISSUE: 4
Year: 2017
Page: [380 - 389]
Pages: 10
DOI: 10.2174/1570161115666170202160948
Price: $58