Surrogates of Insulin Sensitivity and Indices of Cardiometabolic Profile in Obesity
Djordje S. Popovic,
Background and Objectives: Obesity is often associated with insulin resistance (IR). We
considered different IR indexes: the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR)
index, the two specimen (0 and 120 min) oral glucose tolerance test Matsuda Index (MI) and the Homeostasis
Model Assessment-Adiponectin (HOMA-AD) index. These IR indexes were compared with
indicators of the cardiometabolic profile.
Method: This cross-sectional study enrolled 60 obese individuals without previous history of diabetes.
Anthropometrical, ultrasound and laboratory examinations were conducted.
Results: All 3 indexes significantly correlated with indicators of central obesity, systolic and diastolic
blood pressure, inflammation parameters, liver enzymes, HbA1c and some lipid parameters. The majority
of correlation coefficients were the highest for HOMA-AD, but only the difference in correlation
with waist circumference comparing with MI was statistically significant. HOMA-IR directly, and MI
indirectly, significantly correlated with age, while HOMA-AD significantly directly correlated with the
mean carotid artery intima media thickness (CAIMT). MI showed the best performances in predicting
non-alcoholic fatty liver disease and pathologically increased CAIMT; HOMA-AD was the best in predicting
metabolic syndrome, while HOMA-IR demonstrated the poorest performances in the prediction
of all 3 conditions. There were no statistically significant differences in predicting performances of the
Conclusion: The HOMA-AD and MI are not superior compared with the HOMA-IR, in the identification
of obese individuals with a proatherogenic cardiometabolic profile.
Keywords: Adiponectin, adipose tissue, atherosclerosis, insulin resistance, insulin sensitivity, metabolic syndrome, nonalcoholic
fatty liver disease, obesity.
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