Abstract
Introduction: The family of calcium-dependent protein kinases (CDPKs) carries a kinase domain fused to a calmodulin-like domain. The presence of protein kinases devoid of clear mammalian eukaryotic protein kinase orthologues makes them potential targets for therapeutic development. Recent studies on CDPKs have inspired an important primary regulator of calcium (intracellular Ca2+ signaling), which is extensively reported to play a critical role in various stages of the apicomplexan life cycle such as microneme secretion of adhesions, cell invasion, gamete maturation, gliding motility and egress of Plasmodium Spp.
Conclusion: Understanding and identifying these essential cytoregulatory components of the parasite is important for drug targets development and therapeutic intervention.Keywords: CDPK, Calcium signalling, Plasmodium parasites, drug target, Malaria, CDPK.
Current Topics in Medicinal Chemistry
Title:Calcium Dependent Protein Kinases (CDPKs): Key to Malaria Eradication
Volume: 17 Issue: 19
Author(s): Kavita Kadian, Yash Gupta, Prakasha Kempaiah, Nikesh Gupta, Arun Sharma and Manmeet Rawat*
Affiliation:
- Department of Internal Medicine, University of New Mexico School of Medicine, Health Sciences Center, MSC10-5550, Albuquerque, NM87131-0001,United States
Keywords: CDPK, Calcium signalling, Plasmodium parasites, drug target, Malaria, CDPK.
Abstract: Introduction: The family of calcium-dependent protein kinases (CDPKs) carries a kinase domain fused to a calmodulin-like domain. The presence of protein kinases devoid of clear mammalian eukaryotic protein kinase orthologues makes them potential targets for therapeutic development. Recent studies on CDPKs have inspired an important primary regulator of calcium (intracellular Ca2+ signaling), which is extensively reported to play a critical role in various stages of the apicomplexan life cycle such as microneme secretion of adhesions, cell invasion, gamete maturation, gliding motility and egress of Plasmodium Spp.
Conclusion: Understanding and identifying these essential cytoregulatory components of the parasite is important for drug targets development and therapeutic intervention.Export Options
About this article
Cite this article as:
Kadian Kavita, Gupta Yash, Kempaiah Prakasha, Gupta Nikesh, Sharma Arun and Rawat Manmeet*, Calcium Dependent Protein Kinases (CDPKs): Key to Malaria Eradication, Current Topics in Medicinal Chemistry 2017; 17 (19) . https://dx.doi.org/10.2174/1568026617666170130112714
DOI https://dx.doi.org/10.2174/1568026617666170130112714 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements