Abstract
1,3,4-Oxadiazole derivatives are found to have a wide range of pharmacological activities and attracting the researchers to work on this nucleus. Literature survey indicates that many 1,3,4- oxadiazoles have been synthesized with the aim to get compounds of significant anti-inflammatory and analgesic activities with reduced adverse effects. The purpose of this review is to compile the reports on 1,3,4-oxadiazole derivatives possessing anti-inflammatory and analgesic activities. The review also includes the reports on 1,3,4-oxadiazole derivatives of existing NSAIDs in the last ten years.
Keywords: Analgesic, anti-inflammatory, scaffold, COX, 1, 3, 4-Oxadiazole, NSAIDs.
Mini-Reviews in Medicinal Chemistry
Title:Exploring 1,3,4-Oxadiazole Scaffold for Anti-inflammatory and Analgesic Activities: A Review of Literature From 2005-2016
Volume: 18 Issue: 3
Author(s): Gita Chawla*, Baby Naaz and Anees A. Siddiqui
Affiliation:
- Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110062,India
Keywords: Analgesic, anti-inflammatory, scaffold, COX, 1, 3, 4-Oxadiazole, NSAIDs.
Abstract: 1,3,4-Oxadiazole derivatives are found to have a wide range of pharmacological activities and attracting the researchers to work on this nucleus. Literature survey indicates that many 1,3,4- oxadiazoles have been synthesized with the aim to get compounds of significant anti-inflammatory and analgesic activities with reduced adverse effects. The purpose of this review is to compile the reports on 1,3,4-oxadiazole derivatives possessing anti-inflammatory and analgesic activities. The review also includes the reports on 1,3,4-oxadiazole derivatives of existing NSAIDs in the last ten years.
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Cite this article as:
Chawla Gita*, Naaz Baby and Siddiqui A. Anees, Exploring 1,3,4-Oxadiazole Scaffold for Anti-inflammatory and Analgesic Activities: A Review of Literature From 2005-2016, Mini-Reviews in Medicinal Chemistry 2018; 18 (3) . https://dx.doi.org/10.2174/1389557517666170127121215
DOI https://dx.doi.org/10.2174/1389557517666170127121215 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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