Indicators of Cardiovascular Risk in Metabolic Syndrome: Long Term Follow-up in Italian Patients

Title:Indicators of Cardiovascular Risk in Metabolic Syndrome: Long Term Follow-up in Italian Patients

Volume: 15 Issue: 3

Author(s): Giuliana Mombelli*, Chiara Pavanello, Samuela Castelnuovo, Raffaella Bosisio, Sara Simonelli, Franco Pazzucconi and Cesare Riccardo Sirtori

Affiliation:

• Centro Dislipidemie, Dip. Cardiotoracovascolare, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 3, 20162 Milano,Italy

Keywords: Metabolic syndrome, carotid intima media thickness, waist-to-height ratio, waist circumference, cardiovascular risk.

Abstract: Background: Cardiovascular risk (CV) factors associated with the metabolic syndrome (MetS) may vary in different populations. In some, hypertension may be the major determinant, in others are low high-density lipoprotein cholesterol (HDL-C), high triglycerides, or another component.

Subjects and Methods: Subjects included in this analysis were identified in 2006, among those attending the Lipid Clinic of the Niguarda Hospital, and followed up through to 2013. Patient characteristics (including the occurrence of CV events) were obtained from electronic medical records. MetS was diagnosed according to the American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI) guidelines. The carotid intima media thickness (cIMT) was also followed in these patients over the years.

Results: After 7 years a total of 858 subjects had a complete follow-up; 271 of those had MetS. Patients developing a CV event showed elevated baseline cIMT (e.g. cIMTmax ≥ 2.4 mm in males and ≥ 2.2 mm in females); moreover the cIMT in MetS patients was higher at baseline and the rise over 7 years was larger compared with patients without MetS. By examining each body variable for MetS we found that a waist to height ratio (WHtR) ≥ 0.5 was present in nearly all subjects with a CV event.

Conclusion: The follow-up data of a series of Italian patients with and without MetS, clearly indicates that the former have a raised cIMT and their arterial IMT progression is greater and the presence of a larger WHtR is apparently linked to a higher incidence of CV events.

Cite this article as:

Mombelli Giuliana*, Pavanello Chiara, Castelnuovo Samuela, Bosisio Raffaella, Simonelli Sara, Pazzucconi Franco and Sirtori Riccardo Cesare, Indicators of Cardiovascular Risk in Metabolic Syndrome: Long Term Follow-up in Italian Patients, Current Vascular Pharmacology 2017; 15 (3) . https://dx.doi.org/10.2174/1570161115666170126124149

DOI https://dx.doi.org/10.2174/1570161115666170126124149	Print ISSN 1570-1611
Publisher Name Bentham Science Publisher	Online ISSN 1875-6212