Abstract
Background: Acetic acid alone when employed as a solvent under ultrasound irradiation has been found to be effective for the three-component reaction involving ethyl-5- amino-1H-pyrazole-4-carboxylate, aromatic aldehydes and terminal alkynes in the presence of aerial oxygen.
Methods: The catalyst / promoter / ligand free method afforded a range of pyrazolo[1,5-a] pyrimidines as potential and new cytotoxic agents. Results and Conclusion: While some of these compounds showed cytotoxicities against two breast cancer cell lines one of them was found to be promising.Keywords: Ultrasound, MCR, acetic acid, pyrazolo[1, 5-a]pyrimidine, drug discovery, anti-tumor.
Letters in Drug Design & Discovery
Title:Ultrasound-Assisted 3-Component Reaction in Acetic Acid Alone: Catalyst / Promoter / Ligand Free Synthesis of Bioactive Pyrazolo[1,5-a]pyrimidines
Volume: 14 Issue: 10
Author(s): Namburi Suresh, Bodapati Veera Durgarao, A. Ratnakar, Sunder Kumar Kolli, Mohd Ashraf Ashfaq, Mandava V. Basaveswara Rao*Manojit Pal*
Affiliation:
- Department of Chemistry, Krishna University, Machilipatnam, AP,India
- Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046,India
Keywords: Ultrasound, MCR, acetic acid, pyrazolo[1, 5-a]pyrimidine, drug discovery, anti-tumor.
Abstract: Background: Acetic acid alone when employed as a solvent under ultrasound irradiation has been found to be effective for the three-component reaction involving ethyl-5- amino-1H-pyrazole-4-carboxylate, aromatic aldehydes and terminal alkynes in the presence of aerial oxygen.
Methods: The catalyst / promoter / ligand free method afforded a range of pyrazolo[1,5-a] pyrimidines as potential and new cytotoxic agents. Results and Conclusion: While some of these compounds showed cytotoxicities against two breast cancer cell lines one of them was found to be promising.Export Options
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Cite this article as:
Suresh Namburi, Durgarao Veera Bodapati, Ratnakar A., Kolli Kumar Sunder, Ashfaq Ashraf Mohd, Basaveswara Rao V. Mandava*, Pal Manojit*, Ultrasound-Assisted 3-Component Reaction in Acetic Acid Alone: Catalyst / Promoter / Ligand Free Synthesis of Bioactive Pyrazolo[1,5-a]pyrimidines, Letters in Drug Design & Discovery 2017; 14 (10) . https://dx.doi.org/10.2174/1570180814666170126120408
DOI https://dx.doi.org/10.2174/1570180814666170126120408 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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