Ultrasound-Assisted 3-Component Reaction in Acetic Acid Alone: Catalyst / Promoter / Ligand Free Synthesis of Bioactive Pyrazolo[1,5-a]pyrimidines

Title:Ultrasound-Assisted 3-Component Reaction in Acetic Acid Alone: Catalyst / Promoter / Ligand Free Synthesis of Bioactive Pyrazolo[1,5-a]pyrimidines

Volume: 14 Issue: 10

Author(s): Namburi Suresh, Bodapati Veera Durgarao, A. Ratnakar, Sunder Kumar Kolli, Mohd Ashraf Ashfaq, Mandava V. Basaveswara Rao*Manojit Pal*

Affiliation:

• Department of Chemistry, Krishna University, Machilipatnam, AP,India

• Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046,India

Keywords: Ultrasound, MCR, acetic acid, pyrazolo[1, 5-a]pyrimidine, drug discovery, anti-tumor.

Abstract: Background: Acetic acid alone when employed as a solvent under ultrasound irradiation has been found to be effective for the three-component reaction involving ethyl-5- amino-1H-pyrazole-4-carboxylate, aromatic aldehydes and terminal alkynes in the presence of aerial oxygen.

Cite this article as:

Suresh Namburi, Durgarao Veera Bodapati, Ratnakar A., Kolli Kumar Sunder, Ashfaq Ashraf Mohd, Basaveswara Rao V. Mandava*, Pal Manojit*, Ultrasound-Assisted 3-Component Reaction in Acetic Acid Alone: Catalyst / Promoter / Ligand Free Synthesis of Bioactive Pyrazolo[1,5-a]pyrimidines, Letters in Drug Design & Discovery 2017; 14 (10) . https://dx.doi.org/10.2174/1570180814666170126120408