Abstract
Drug development has moved along way forward from the days of with doctors peddling cauldrons of herbs and spices, however, the process can still miss opportunities for full exploitation of a drug’s potential. Drug reprofiling provides a chance for an established or a forgotten drug to move into a new area of therapy, whether related to the known effects or in a completely new area. In an era of environmental awareness and spiraling costs for traditional drug development, a strategy to squeeze every benefit out of drugs with known safety, tolerability and pharmacological parameters must be a strategically sound desire. We explore examples of success in reprofiling, draw comparisons between techniques, and finally provide two examples from the Valirx plc development pipeline currently undergoing the process.
Keywords: Reprofiling, development, techniques, health economics, risperidone, cancer.
Current Drug Discovery Technologies
Title:Pimping up Drugs Recovered, Superannuated and Under Exploited Drugs - An Introduction to the Basics of Drug Reprofiling
Volume: 14 Issue: 2
Author(s): Suzanne J. Dilly*George S. Morris
Affiliation:
- ValiSeek Limited, London,United Kingdom
Keywords: Reprofiling, development, techniques, health economics, risperidone, cancer.
Abstract: Drug development has moved along way forward from the days of with doctors peddling cauldrons of herbs and spices, however, the process can still miss opportunities for full exploitation of a drug’s potential. Drug reprofiling provides a chance for an established or a forgotten drug to move into a new area of therapy, whether related to the known effects or in a completely new area. In an era of environmental awareness and spiraling costs for traditional drug development, a strategy to squeeze every benefit out of drugs with known safety, tolerability and pharmacological parameters must be a strategically sound desire. We explore examples of success in reprofiling, draw comparisons between techniques, and finally provide two examples from the Valirx plc development pipeline currently undergoing the process.
Export Options
About this article
Cite this article as:
Dilly J. Suzanne*, Morris S. George, Pimping up Drugs Recovered, Superannuated and Under Exploited Drugs - An Introduction to the Basics of Drug Reprofiling, Current Drug Discovery Technologies 2017; 14 (2) . https://dx.doi.org/10.2174/1570163814666170117120005
DOI https://dx.doi.org/10.2174/1570163814666170117120005 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Tumor Suppression by DNA Base Excision Repair
Mini-Reviews in Medicinal Chemistry Retinoids as Therapeutic Agents: Today and Tomorrow
Mini-Reviews in Medicinal Chemistry Role of NUCB2/nesfatin-1 as a Possible Biomarker
Current Pharmaceutical Design Patent Selections:
Recent Patents on Anti-Cancer Drug Discovery Tumor Promoters - Microcystin-LR, Nodularin and TNF-α and Human Cancer Development
Anti-Cancer Agents in Medicinal Chemistry Targeting the NF-κB pathway in prostate cancer: a promising therapeutic approach?
Current Drug Targets Role of Plasmacytoid Dendritic Cells in Lung-Associated Inflammation
Recent Patents on Inflammation & Allergy Drug Discovery Recent Studies and Biological Aspects of Substantial Indole Derivatives with Anti-cancer Activity
Current Organic Chemistry Natural Compounds in Anti-Leukaemic Therapy: A Review
Mini-Reviews in Medicinal Chemistry HR+, HER2– Advanced Breast Cancer and CDK4/6 Inhibitors: Mode of Action, Clinical Activity, and Safety Profiles
Current Cancer Drug Targets Current Concepts on Cardiovascular Stent Devices
Mini-Reviews in Medicinal Chemistry Anticancer Properties of Traditional Chinese Medicine
Combinatorial Chemistry & High Throughput Screening High-accuracy Automated Diagnosis of Parkinson's Disease
Current Medical Imaging The True Face of the Revolution in Oncology Drug Development: A Personal Reflection
Current Clinical Pharmacology The Gatekeeping Function in Personalized Medicine Initiatives
Current Pharmacogenomics and Personalized Medicine Liposomes: An Emerging Approach for the Treatment of Cancer
Current Pharmaceutical Design Stem Cell Guardians – Old and New Perspectives in LSC Biology
Current Drug Targets Radiometal Complexes in Molecular Imaging and Therapy
Current Medicinal Chemistry Role of Antioxidants for the Treatment of Cardiovascular Diseases: Challenges and Opportunities
Current Pharmaceutical Design Transcriptome Analysis of mRNA in Uterine Leiomyoma Using Next-generation RNA Sequencing
Anti-Cancer Agents in Medicinal Chemistry