Common Therapeutic Modalities Against Diabetes and Associated Cardiovascular Disease

Title:Common Therapeutic Modalities Against Diabetes and Associated Cardiovascular Disease

Volume: 15 Issue: 4

Author(s): Nasimudeen R Jabir, Chelapram Kandy Firoz, Ghulam Md Ashraf, Syed Kashif Zaidi, Shazi Shakil, Mohammad Amjad Kamal and Shams Tabrez*

Affiliation:

• King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589,Saudi Arabia

Keywords: Cardiovascular disease, diabetes mellitus, glycaemic imbalance, obesity, oxidative stress.

Abstract: Despite recent advances in medical research, the incidence of diabetes and cardiovascular disease (CVD)-induced fatal events is increasing. The literature point towards several co-occurring pathways that could lead to terminal complications related with these diseases. Different pathophysiological alterations such as hyperglycaemia, hyperinsulinaemia, insulin resistance, obesity, endothelial dysfunction and oxidative stress lead to the initiation and progression of atherosclerotic plaques. In view of the continuous rise in fatal events and overlapping pathological conditions associated with CVD and diabetes, there is a critical need to develop a common treatments against these diseases. The present review highlights the possible use of common drugs that could target diabetes and associated CVD.

Cite this article as:

Jabir R Nasimudeen, Firoz Kandy Chelapram, Ashraf Md Ghulam, Zaidi Kashif Syed, Shakil Shazi, Kamal Amjad Mohammad and Tabrez Shams*, Common Therapeutic Modalities Against Diabetes and Associated Cardiovascular Disease, Current Vascular Pharmacology 2017; 15 (4) . https://dx.doi.org/10.2174/1570161115666170105125034