Abstract
Background: Heterocyclic scaffolds widely occur in natural products and pharmaceutical molecules and because of their broad biological activities, the synthesis of such frameworks with diverse approaches is one of the most attractive fields in modern organic chemistry. Recently, cascade reactions catalyzed by transition metals made astounding advances in the synthesis of heterocyclic compounds for their step economy. Among them, gold-catalyzed cascade reactions emerged as important tools to construct complicated heterocyclic architecture from simple precursors in the past decade.
Objective: This review presents an overview of recent advances in gold-catalyzed cascade reactions to generate diverse heterocyclic scaffolds and its applications in total synthesis of natural products.Keywords: Gold, transition metals, cascade reactions, tandem reactions, domino reactions, heterocycles, natural products.
Current Organic Chemistry
Title:Recent Advances in the Synthesis of Heterocycles via Gold-catalyzed Cascade Reactions: A Review
Volume: 21 Issue: 15
Author(s): Feng Gao, Yu Zhou and Hong Liu*
Affiliation:
- CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203,China
Keywords: Gold, transition metals, cascade reactions, tandem reactions, domino reactions, heterocycles, natural products.
Abstract: Background: Heterocyclic scaffolds widely occur in natural products and pharmaceutical molecules and because of their broad biological activities, the synthesis of such frameworks with diverse approaches is one of the most attractive fields in modern organic chemistry. Recently, cascade reactions catalyzed by transition metals made astounding advances in the synthesis of heterocyclic compounds for their step economy. Among them, gold-catalyzed cascade reactions emerged as important tools to construct complicated heterocyclic architecture from simple precursors in the past decade.
Objective: This review presents an overview of recent advances in gold-catalyzed cascade reactions to generate diverse heterocyclic scaffolds and its applications in total synthesis of natural products.Export Options
About this article
Cite this article as:
Gao Feng, Zhou Yu and Liu Hong*, Recent Advances in the Synthesis of Heterocycles via Gold-catalyzed Cascade Reactions: A Review, Current Organic Chemistry 2017; 21 (15) . https://dx.doi.org/10.2174/1385272821666170102144500
DOI https://dx.doi.org/10.2174/1385272821666170102144500 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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