Abstract
Diabetic neuropathy is the most common complication of diabetes mellitus and a major factor associated with foot ulcers and amputations in patients with diabetes. Diagnosing diabetic neuropathy in early stages may reduce the risk for comorbidities. However, it still represents a major challenge for the healthcare providers, despite the complexity of available techniques. Discovering new serum biomarkers, useful for early diagnosis of diabetic neuropathy and monitoring the disease progression is of growing interest for the scientific research. In this regard, the field of proteomics is extremely promising. Mass spectrometry technology and bioinformatic analysis of proteomic data accelerated the detection of biomarkers related to peripheral nervous system pathology. Herein, we analyze what role proteomics approaches play in the modern diagnostic strategy of diabetic neuropathy.
Keywords: Biomarker, diabetes, diabetic neuropathy, diagnosis, mass spectrometry, proteomics.
Current Proteomics
Title:The Quest for Novel Biomarkers in Early Diagnosis of Diabetic Neuropathy
Volume: 14 Issue: 2
Author(s): Mihaela Adriana Ghita, Constantin Caruntu*, Daniela Lixandru, Adriana Pitea, Alexandra Batani and Daniel Boda
Affiliation:
- Department of Physiology, “Carol Davila” University of Medicine and Pharmacy, 050474, Bucharest,Romania
Keywords: Biomarker, diabetes, diabetic neuropathy, diagnosis, mass spectrometry, proteomics.
Abstract: Diabetic neuropathy is the most common complication of diabetes mellitus and a major factor associated with foot ulcers and amputations in patients with diabetes. Diagnosing diabetic neuropathy in early stages may reduce the risk for comorbidities. However, it still represents a major challenge for the healthcare providers, despite the complexity of available techniques. Discovering new serum biomarkers, useful for early diagnosis of diabetic neuropathy and monitoring the disease progression is of growing interest for the scientific research. In this regard, the field of proteomics is extremely promising. Mass spectrometry technology and bioinformatic analysis of proteomic data accelerated the detection of biomarkers related to peripheral nervous system pathology. Herein, we analyze what role proteomics approaches play in the modern diagnostic strategy of diabetic neuropathy.
Export Options
About this article
Cite this article as:
Ghita Adriana Mihaela , Caruntu Constantin *, Lixandru Daniela , Pitea Adriana , Batani Alexandra and Boda Daniel , The Quest for Novel Biomarkers in Early Diagnosis of Diabetic Neuropathy, Current Proteomics 2017; 14 (2) . https://dx.doi.org/10.2174/1570164614666161228122259
DOI https://dx.doi.org/10.2174/1570164614666161228122259 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
Call for Papers in Thematic Issues
Mass spectrometry data acquisition and analysis for proteomics
The Thematic Issue on "Mass spectrometry data acquisition and analysis for proteomics" aims to explore the latest advancements and challenges in the field of proteomics through the lens of mass spectrometry. Proteomics, the large-scale study of proteins and their functions, plays a crucial role in understanding various biological processes and ...read more
Peptides: State-of-Art and Commercialisation Hurdles
The Editors of the Current Proteomics (CP) journal are highly privileged to welcome scientists to submit their scientific research and review articles to be considered for publication in the upcoming thematic issue. The topics should cover various aspects of peptides in regard to their synthetic methodologies, formulation approaches, pharmacological challenges, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Exercise and Nutraceuticals: Eminent Approach for Diabetic Neuropathy
Current Molecular Pharmacology Selective Carbohydrate Recognition by Synthetic Receptors in Aqueous Solution
Current Organic Chemistry Recent Studies of Aldose Reductase Enzyme Inhibition for Diabetic Complications
Current Medicinal Chemistry Pain Management in Hematological Patients with Major Organ Dysfunctions and Comorbid Illnesses
Cardiovascular & Hematological Agents in Medicinal Chemistry Beneficial Extracardiac Effects of Cardiovascular Medications
Current Cardiology Reviews Emerging Therapy for Diabetic Neuropathy: Cell Therapy Targeting Vessels and Nerves
Endocrine, Metabolic & Immune Disorders - Drug Targets Alstrom Syndrome: Genetics and Clinical Overview
Current Genomics Computational Insights into the Role of Glutathione in Oxidative Stress
Current Neurovascular Research Mitochondria-Targeted Antioxidants as a Therapeutic Strategy for Protecting Endothelium in Cardiovascular Diseases
Current Medicinal Chemistry Is Inflammation a Common Retinal-Renal-Nerve Pathogenic Link in Diabetes?
Current Diabetes Reviews Therapeutic Potential of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors for the Treatment of Retinal and Eye Diseases
CNS & Neurological Disorders - Drug Targets Herbs for Effective Treatment of Diabetes Mellitus Wounds: Medicinal Chemistry and Future Therapeutic Options
Mini-Reviews in Medicinal Chemistry TAGE (Toxic AGEs) Theory in Diabetic Complications
Current Molecular Medicine Potentials of ES Cell Therapy in Neurodegenerative Diseases
Current Pharmaceutical Design Mitochondria-Mediated Oxidative Stress: Old Target for New Drugs
Current Medicinal Chemistry Neuronal and Glial Cell Abnormality as Predictors of Progression of Diabetic Retinopathy
Current Pharmaceutical Design The Potential Role of Angiotensin Converting Enzyme and Vasopeptidase Inhibitors in the Treatment of Diabetic Neuropathy
Current Drug Targets Editorial (Hot Topic: Synthetic, Natural and Related Compounds: New Approach to Chronic Diseases Studies)
Current Topics in Medicinal Chemistry Renal Complications of Fabry Disease
Current Pharmaceutical Design Editorial (Diabetes, Obesity and Vascular Disease - An Update)
Current Pharmaceutical Design