Abstract
Gliomas are the most common primary malignant brain tumors, which have a universally fatal outcome. Current standard treatment for glioma patients is surgical removal followed by radiotherapy and adjuvant chemotherapy. Due to therapeutic resistance and tumor recurrence, efforts are ongoing to identify the molecules that are fundamental to regulate the tumor progression and provide additional methods for individual treatment of glioma patients.
By studying the initiation and maintenance of glioma, studies focused on the targets of tyrosine kinase receptors including EGFR, PDGFR and other crucial signal pathways such as PI3K/AKT and RAS/RAF/MAPK pathway. Furthermore, recent advances in targeting immunotherapy and stem cell therapy also brought numerous strategies to glioma treatment. This article reviewed the researches focused on the advanced strategies of various target therapies for improving the glioma treatment efficacy, and discussed the challenges and future directions for glioma therapy.Keywords: Glioma, clinical trials, targeted therapy, cell signal transduction pathway, glioma stem cell, Immunotherapy.
Current Medicinal Chemistry
Title:Recent Advances in Targeted Therapy for Glioma
Volume: 24 Issue: 13
Author(s): Lin Lin, Jinquan Cai*Chuanlu Jiang*
Affiliation:
- Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, No.246 XueFu Road, NanGang District, Harbin, Heilongjiang Province 150086,China
- Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, No.246 XueFu Road, NanGang District, Harbin, Heilongjiang Province 150086,China
Keywords: Glioma, clinical trials, targeted therapy, cell signal transduction pathway, glioma stem cell, Immunotherapy.
Abstract: Gliomas are the most common primary malignant brain tumors, which have a universally fatal outcome. Current standard treatment for glioma patients is surgical removal followed by radiotherapy and adjuvant chemotherapy. Due to therapeutic resistance and tumor recurrence, efforts are ongoing to identify the molecules that are fundamental to regulate the tumor progression and provide additional methods for individual treatment of glioma patients.
By studying the initiation and maintenance of glioma, studies focused on the targets of tyrosine kinase receptors including EGFR, PDGFR and other crucial signal pathways such as PI3K/AKT and RAS/RAF/MAPK pathway. Furthermore, recent advances in targeting immunotherapy and stem cell therapy also brought numerous strategies to glioma treatment. This article reviewed the researches focused on the advanced strategies of various target therapies for improving the glioma treatment efficacy, and discussed the challenges and future directions for glioma therapy.Export Options
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Cite this article as:
Lin Lin, Cai Jinquan*, Jiang Chuanlu*, Recent Advances in Targeted Therapy for Glioma, Current Medicinal Chemistry 2017; 24 (13) . https://dx.doi.org/10.2174/0929867323666161223150242
DOI https://dx.doi.org/10.2174/0929867323666161223150242 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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